Evidence map›Paper›PMID 35646722›Full record

ArticleFrontiers in cellular and infection microbiology2022

Exploring the Causal Effect of Constipation on Parkinson's Disease Through Mediation Analysis of Microbial Data.

Shih-Chen Fu, Ling-Chieh Shih, Pei-Hua Wu, Yi-Chen Hsieh, Chung-Han Lee, Sheng-Hsuan Lin, Hsiuying Wang

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Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shih-Chen FuInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Ling-Chieh ShihDepartment of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Pei-Hua WuInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Yi-Chen HsiehInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Chung-Han LeeInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Sheng-Hsuan LinInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
Hsiuying WangInstitute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Parkinson's disease (PD) is a worldwide neurodegenerative disease with an increasing global burden, while constipation is an important risk factor for PD. The gastrointestinal tract had been proposed as the origin of PD in Braak's gut-brain axis hypothesis, and there is increasing evidence indicating that intestinal microbial alteration has a role in the pathogenesis of PD. In this study, we aim to investigate the role of intestinal microbial alteration in the mechanism of constipation-related PD. Methods: We adapted our data from Hill-Burns et al., in which 324 participants were enrolled in the study. The 16S rRNA gene sequence data were processed, aligned, and categorized using DADA2. Mediation analysis was used to test and quantify the extent by which the intestinal microbial alteration explains the causal effect of constipation on PD incidence. Results: We found 18 bacterial genera and 7 species significantly different between groups of constipated and non-constipated subjects. Among these bacteria, nine genera and four species had a significant mediation effect between constipation and PD. All of them were short-chain fatty acid (SCFA)-producing bacteria that were substantially related to PD. Results from the mediation analysis showed that up to 76.56% of the effect of constipation on PD was mediated through intestinal microbial alteration. Conclusion: Our findings support that gut dysbiosis plays a critical role in the pathogenesis of constipation-related PD, mostly through the decreasing of SCFA-producing bacteria, indicating that probiotics with SCFA-producing bacteria may be promising in the prevention and treatment of constipation-related PD. Limitations: 1) Several potential confounders that should be adjusted were not provided in the original dataset. 2) Our study was conducted based on the assumption of constipation being the etiology of PD; however, constipation and PD may mutually affect each other. 3) Further studies are necessary to explain the remaining 23.44% effect leading to PD by constipation.

Indexed as

Gastrointestinal MicrobiomeNeurodegenerative DiseasesParkinson DiseaseBacteriaConstipationFatty Acids, VolatileHumansMediation AnalysisRNA, Ribosomal, 16SFatty Acids, VolatileRNA, Ribosomal, 16Sconstipationintestinal microbial changesmediation analysismicrobiomeParkinson’s disease

Identifiers

PMID35646722
PMCPMC9130588

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.