Evidence map›Paper›PMID 35646627›Full record

ArticleFrontiers in oncology2022

Caterina Puglisi, Raffaella Giuffrida, Giuseppina Borzì, Salvatore Illari, Francesco Paolo Caronia, Paolo Di Mattia, Cristina Colarossi, Gianluca Ferini, Emanuele Martorana, Giovanni Sette and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Feasibility, safety, and clinical outcomes analysis of dense-lattice radiation therapy in palliative care for cancer patients´.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Definitive (chemo)radiotherapy of enteric-type adenocarcinoma of the lung: time to unmask an underrated treatment option?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Caterina PuglisiGenomics and Experimental oncology unit, IOM Ricerca, Viagrande, Italy.
Raffaella GiuffridaGenomics and Experimental oncology unit, IOM Ricerca, Viagrande, Italy.
Giuseppina BorzìOperative Unit of Radiotherapy, Rem Radioterapia, Viagrande, Italy.
Salvatore IllariUnit of Radiotherapy, Fondazione IOM, Viagrande, Italy.
Francesco Paolo CaroniaUnit of Thoracic Surgery, Azienda di Rilievo Nazionale ad Alta Specializzazione (ARNAS) Civico, Palermo, Italy.
Paolo Di MattiaDepartment of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, Italy.
Cristina ColarossiDepartment of Experimental Oncology, Mediterranean Institute of Oncology, Viagrande, Italy.
Gianluca FeriniOperative Unit of Radiotherapy, Rem Radioterapia, Viagrande, Italy.
Emanuele MartoranaGenomics and Experimental oncology unit, IOM Ricerca, Viagrande, Italy.
Giovanni SetteDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Adriana EramoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Aurelio LoricoGenomics and Experimental oncology unit, IOM Ricerca, Viagrande, Italy.
Alfio Di GraziaOperative Unit of Radiotherapy, Rem Radioterapia, Viagrande, Italy.
Stefano ForteGenomics and Experimental oncology unit, IOM Ricerca, Viagrande, Italy.
Istituto Superiore di Sanità · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITTouro University Nevada · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy represents a first-line treatment for many inoperable lung tumors. New technologies offer novel opportunities for the treatment of lung cancer with the administration of higher doses of radiation in smaller volumes. Because both therapeutic and toxic treatment effects are dose-dependent, it is important to identify a minimal dose protocol for each individual patient that maintains efficacy while decreasing toxicity. Cancer stem cells sustain tumor growth, promote metastatic dissemination, and may give rise to secondary resistance. The identification of effective protocols targeting these cells may improve disease-free survival of treated patients. In this work, we evaluated the existence of individual profiles of sensitivity to radiotherapy in patient-derived cancer stem cells (CSCs) using both

Indexed as

cancer stem cellsin vitro modelinglung cancerpersonalized radiotherapyradiotherapy-induced toxicity

Identifiers

PMID35646627
PMCPMC9133629
OpenAlexW4280501628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.