Evidence map›Paper›PMID 35646526›Full record

ArticleActa pharmaceutica Sinica. B2022

Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment.

Lihuan Shang, Xue Jiang, Ting Yang, Hongbo Xu, Qi Xie, Mei Hu, Conglian Yang, Li Kong, Zhiping Zhang

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lihuan ShangTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Xue JiangTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Ting YangTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Hongbo XuTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Qi XieTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Mei HuTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Conglian YangTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Li KongTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhiping ZhangTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.
Huazhong University of Science and Technology · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the development of chemo-immunotherapy, many efforts have been focusing on designing suitable carriers to realize the co-delivery of chemotherapeutic and immunotherapeutic with different physicochemical properties and mechanisms of action. Besides, rapid drug release at the tumor site with minimal drug degradation is also essential to facilitate the antitumor effect in a short time. Here, we reported a cancer cell membrane-coated pH-responsive nanogel (NG@M) to co-deliver chemotherapeutic paclitaxel (PTX) and immunotherapeutic agent interleukin-2 (IL-2) under mild conditions for combinational treatment of triple-negative breast cancer. In the designed nanogels, the synthetic copolymer PDEA-

Indexed as

Biomimetic modificationCancer cell membraneChemo-immunotherapyInterleukin-2NanogelPaclitaxelpH-responsiveRapid release

Identifiers

PMID35646526
PMCPMC9136611
OpenAlexW3214648760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.