Evidence map›Paper›PMID 35646499›Full record

ArticleNMC case report journal2022

Rupture of Vertebral Artery Dissecting Aneurysm after mRNA Anti-COVID-19 Vaccination: A Report of Two Cases.

Kohei Chida, Tatsuhiko Takahashi, Suguru Igarashi, Kentaro Fujimoto, Yasushi Ogasawara, Shunrou Fujiwara, Takahiro Koji, Yoshitaka Kubo, Kuniaki Ogasawara

Open access · diamondAbstract readCase Reports
In one paragraph

Article in NMC case report journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Neurovascular Adverse Effects of Sars-Cov-2 Vaccination.Drug design, development and therapy · 2024
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kohei ChidaDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Tatsuhiko TakahashiDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Suguru IgarashiDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Kentaro FujimotoDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Yasushi OgasawaraDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Shunrou FujiwaraDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Takahiro KojiDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Yoshitaka KuboDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Kuniaki OgasawaraDepartment of Neurosurgery, Iwate Medical University, Shiwa, Iwate, Japan.
Iwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic continues to spread around the world, and widespread vaccination is considered the most effective way to end it. Although the efficacy of COVID-19 vaccines has been confirmed, their safety remains a concern. In this paper, we report two cases of ruptured vertebral artery dissecting aneurysm (VADA) immediately after messenger RNA (mRNA) anti-COVID-19 vaccination. In Case 1, a 60-year-old woman experienced sudden headache 3 weeks before her first dose of the Moderna mRNA-1273 COVID-19 vaccine. Magnetic resonance imaging showed dilatation of the right vertebral artery (VA) without intracranial hemorrhage. A day after the vaccination, she developed subarachnoid hemorrhage with pulmonary effusion due to a ruptured right VADA. She underwent endovascular internal trapping and parent artery occlusion under general anesthesia. In Case 2, a 72-year-old woman with a previous history of the left VA occlusion due to arterial dissection developed subarachnoid hemorrhage 7 days after the first dose of the Pfizer-BioNTech BNT162b2 COVID-19 mRNA vaccine due to a ruptured right VADA and underwent stent-assisted coil embolization under general anesthesia. The postoperative courses of these two cases were uneventful. The accumulation of more cases and further study are warranted to clarify the relationship between COVID-19 mRNA vaccination and ruptured intracranial dissecting aneurysms.

Indexed as

COVID-19mRNA vaccinerupturevertebral artery dissecting aneurysm

Identifiers

PMID35646499
PMCPMC9119691
OpenAlexW4224979359

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.