Evidence map›Paper›PMID 35645985›Full record

ArticleFrontiers in neurology2022

Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT).

Yaping Wei, Hai Ma, Benjamin Xu, Zhuo Wang, Qiangqiang He, Lishun Liu, Ziyi Zhou, Yun Song, Ping Chen, Jianping Li and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Yaping WeiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Hai MaRongcheng Center for Disease Control and Prevention, Rongcheng, China.
Benjamin XuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Zhuo WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Qiangqiang HeGraduate School at Shenzhen, Tsinghua University, Shenzhen, China.
Lishun LiuGraduate School at Shenzhen, Tsinghua University, Shenzhen, China.
Ziyi ZhouGraduate School at Shenzhen, Tsinghua University, Shenzhen, China.
Yun SongShenzhen Evergreen Medical Institute, Shenzhen, China.
Ping ChenCollege of Pharmacy, Jinan University, Guangzhou, China.
Jianping LiDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Guangyun MaoDepartment of Preventive Medicine, School of Public Health & Management, Wenzhou Medical University, Wenzhou, China.
Binyan WangInstitute for Biomedicine, Anhui Medical University, Hefei, China.
Genfu TangInstitute for Biomedicine, Anhui Medical University, Hefei, China.
Xianhui QinNational Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hao ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Xiping XuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Huiyuan GuoKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China.
China Agricultural University · CNAnhui Medical University · CNPeking University · CNTsinghua University · CNHarvard University · USJinan University · CNNanfang Hospital · CNPeking University First Hospital · CNRongcheng City People's Hospital · CNShenzhen Genoimmune Medical Institute · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin K plays a role in preventing vascular calcification and may have a synergetic influence with vitamin D on cardiovascular health. However, whether this relationship applies to stroke, especially in a high-risk population of hypertensive individuals, remains unclear. The present study aims to study the joint association of low vitamin K1 and D status with first stroke in general hypertensive adults. Methods: This study used a nested, case-control design with data from the China Stroke Primary Prevention Trial. The analysis included 604 first total stroke patients and 604 matched controls from a Chinese population with hypertension. Odds ratios (ORs) and 95% confidence intervals were calculated using conditional logistic regression. Results: There was a non-linear negative association between plasma vitamin K1 and the risk of first total stroke or ischemic stroke in the enalapril-only group. Compared to participants in vitamin K1 quartile 1, a significantly lower risk of total stroke ( Conclusion: Low concentrations of both vitamin K1 and 25(OH)D were associated with increased risk of stroke.

Indexed as

25-hydroxyvitamin Dfirst strokehypertensive adultsnested case-control studyvitamin K1

Identifiers

PMID35645985
PMCPMC9135055
OpenAlexW4283385914

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.