ArticleFrontiers in neurology2022
The Relationship Between Muscle Strength and Cognitive Performance Across Alzheimer's Disease Clinical Continuum.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- The effect of milk fat globule membrane phospholipid supplementation on cognitive function in older adults with subjective memory complaints-a randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2025Trial
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Neuroimage. Reports · 2026Article
- Physical fitness and cognitive function: a cross-sectional study among adults in Qatar.BMJ open · 2026Article
- Article
- Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Short-term daily deflazacort decreases membrane permeability and increases maximum force inAmerican journal of physiology. Cell physiology · 2025Article
- The relationship between grip strength, 6 minute walking distance and working memory in older adults with mild cognitive impairment: an fNIRS study.BMC geriatrics · 2025Article
- The Potential Effects of Sensor-Based Virtual Reality Telerehabilitation on Lower Limb Function in Patients with Chronic Stroke Facing the COVID-19 Pandemic: A Retrospective Case-Control Study.Medical sciences (Basel, Switzerland) · 2025Article
- The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011-2014.Brain and behavior · 2025Article
- Correlation of muscle strength, information processing speed and cognitive function in the elderly with cognitive impairment--evidence from EEG.Frontiers in aging neuroscience · 2025Article
- Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.Frontiers in physiology · 2025Review
- Alzheimer's Disease: Understanding Motor Impairments.Brain sciences · 2024Review
- Review
- The Effectiveness of an Exercise Program on Muscle Strength and Range of Motion on Upper Limbs, Functional Ability and Depression at Early Stage of Dementia.Journal of clinical medicine · 2024Article
- Mitigating cognitive deficits with teriflunomide: unraveling PI3K-modulated behavioral outcomes in mice.Molecular biology reports · 2024Article
- Deficits in force production during multifinger tasks demarcate cognitive dysfunction.Aging clinical and experimental research · 2024Article
- Sarcopenia in subjects with Alzheimer's disease: prevalence and comparison of agreement between EGWSOP1, EGWSOP2, and FNIH criteria.BMC geriatrics · 2024Article
- Sleep and circadian rhythm disruptions in behavioral variant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Correlation of muscle strength, working memory, and activities of daily living in older adults.Frontiers in aging neuroscience · 2024Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline, mostly prominent in the domain of memory, but also associated with other cognitive deficits and non-cognitive symptoms. Reduced muscle strength is common in AD. However, the current understanding of its relationship with cognitive decline is limited. This study investigates the relationship between muscle strength and cognition in patients with AD and mild cognitive impairment (MCI). We enrolled 148 consecutive subjects, including 74 patients with probable AD dementia, 37 MCI, and 37 controls. Participants underwent neuropsychological evaluation focused on attention, working memory, declarative memory and learning. Muscle strength and muscle mass were measured through hand dynamometer and bio-electrical impedance analysis, respectively. Patients with AD dementia were divided with respect to the severity of cognitive impairment into mild and moderate-to-severe patients. Moderate-to-severe patients with AD presented lower handgrip strength than MCI and controls. No differences were observed in muscle mass. In MCI and AD dementia, handgrip strength was associated with overall cognitive functioning, attentional and memory performance. The routine implementation of handgrip strength assessment in the clinical work-up of patients with MCI and AD could potentially represent a simple method to monitor functional and cognitive decline along the disease course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.