Evidence map›Paper›PMID 35645808›Full record

ArticleFrontiers in pharmacology2022

Metformin Regulates Alveolar Macrophage Polarization to Protect Against Acute Lung Injury in Rats Caused by Paraquat Poisoning.

Ding Yuan, Yi Li, Linlin Hou, Fang Yang, Cuicui Meng, Yanwu Yu, Changhua Sun, Guoyu Duan, Zhigao Xu, Guiying Zhu and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Ding YuanDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yi LiEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Linlin HouDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Fang YangDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Cuicui MengDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanwu YuDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Changhua SunDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guoyu DuanDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhigao XuDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guiying ZhuDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jianjun GuoDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Leilei ZhangDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gaiqin YanDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jihong ChenDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanan YangDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yan ZhangDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanxia GaoDepartment of Emergency Medicine, Henan Key Laboratory of Emergency and Trauma Research Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNPeking Union Medical College Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explored the role of metformin (MET) in regulating the polarization of alveolar macrophages to protect against acute lung injury (ALI) in rats caused by paraquat (PQ) poisoning. The

Indexed as

acute lung injuryalveolar macrophagemetforminparaquatpolarization

Identifiers

PMID35645808
PMCPMC9136134
OpenAlexW4280553573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.