Evidence map›Paper›PMID 35645787›Full record

ArticleFrontiers in aging neuroscience2022

Lewy Body-Associated Proteins A-Synuclein (a-syn) as a Plasma-Based Biomarker for Parkinson's Disease.

Xuemiao Zhao, Haijun He, Xi Xiong, Qianqian Ye, Feifei Feng, Shuoting Zhou, Weian Chen, Kai Xia, Shuangjie Qian, Yunjun Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Electroacupuncture alleviates Parkinson's disease-related pain by inhibiting microglial NLRP3-ASC inflammasome in the amygdala.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xuemiao ZhaoDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haijun HeDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xi XiongDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qianqian YeDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Feifei FengDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shuoting ZhouDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Weian ChenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kai XiaDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shuangjie QianDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yunjun YangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chenglong XieDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNFirst Affiliated Hospital of Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To explore the combined diagnostic value of plasma Lewy body-associated proteins (p-Asyn at ser129, total α-syn, and oligomeric α-syn) for the diagnosis of PD versus healthy controls (HCs) and other PD syndromes (PDs), as well as clinical characteristics prediction. Methods: This study included 145 participants: 79 patients with PD, 24 patients with PDs, and 42 HCs. A panel of plasma levels of p-Asyn, total α-syn, and oligomeric α-syn was measured by enzyme-linked immunosorbent assay (ELISA). The primary outcome was the discriminative accuracy of the combined three plasma biomarkers for PD. Results: The mean age was 65.43 (SD, 7.467) in the control group, 64.49 (SD, 8.224) in participants with PD, and 69.25 (SD, 7.952) in PDs. The plasma Lewy body-associated protein levels were significantly higher in patients with PD than in age-matched HCs, However, there was no difference in patients with PD and PDs. Of note, a combination of plasma p-Asyn, total α-syn, and oligomeric α-syn was a better biomarker for discriminating PD from HCs, with an AUC of 0.8552 ( Conclusion: Our results suggested that plasma Lewy body-associated proteins, may serve as a non-invasive biomarker to aid the diagnosis of PD from HCs. In addition, increased plasma Lewy body-associated proteins were not associated with the progression of motor and non-motor symptoms.

Indexed as

biomarkersdiagnosisLewy body-associated proteinsParkinson’s diseaseα-synuclein

Identifiers

PMID35645787
PMCPMC9133668
OpenAlexW4280632386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.