SynthesisFrontiers in aging neuroscience2022
Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies.
Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A systematic review of assessment tools for cognitive frailty: Use, psychometric properties, and clinical utility.The Journal of frailty & aging · 2025Pooled it
- Biopsychosocial frailty and the incident risk of cardio- and cerebrovascular diseases: an 8-year follow-up of the italian longitudinal study on aging.GeroScience · 2026Article
- Comment on "Association of physical activity and life space with cognitive frailty in patients on hemodialysis: the REPnet-HD study".International urology and nephrology · 2026Article
- Association of General Anesthesia Exposure with Cognitive Outcomes in Older Adults: A Cross-Sectional Study in a Korean Cohort.Journal of clinical medicine · 2026Article
- Higher psychological frailty index is associated with incident cardiometabolic diseases in Chinese adults aged 45 years and older.Scientific reports · 2026Article
- The application value of frailty assessment tools in the perioperative period: A narrative review.Journal of anesthesia and translational medicine · 2026Review
- Gender differences in the association between physical frailty and cognitive function among older adults: A cross-sectional study in rural Guizhou, China.Scientific reports · 2026Article
- A longitudinal study on multiple frailty and its associations with depression and social participation in older adults.Scientific reports · 2026Article
- Long-term dental care utilization trajectories as behavioral markers of cognitive aging: a 14-year national cohort study.Frontiers in public health · 2026Article
- A Machine Learning Approach to Modify the Neurocognitive Frailty Index for the Prediction of Cognitive Status in the Canadian Population.Journal of clinical medicine · 2025Article
- Relationships between physical frailty, depressive symptoms, and cognitive ability among community-dwelling older adults in India.BMC public health · 2025Article
- Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive frailty: a useful concept or a source of confusion? Insights from a survey of European geriatricians.BMC geriatrics · 2025Article
- Social Frailty and Social Isolation in the Context of Dementia: A Simultaneous Concept Analysis.International journal of geriatric psychiatry · 2025Review
- Association of Longitudinal Trajectories of Physical Frailty With Dementia Status in Older Adults: A National Cohort Study.International journal of geriatric psychiatry · 2025Article
- Association between coexisting physical, cognitive, and social frailty and sarcopenia in patients undergoing maintenance hemodialysis.Frontiers in medicine · 2025Article
- Association of 3-year change in frailty index with risk of all-cause mortality among older Chinese population: a national cohort study.BMC geriatrics · 2024Article
- Associations of Orthostatic Hypotension and Frailty With Dementia and Mortality in Older Adults: A Population-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults.BMC geriatrics · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a multidimensional syndrome that increases an individual's vulnerability for developing adverse health outcomes, which include dementia. It might serve as a promising target for dementia prevention. However, there are currently no studies summarizing the association between multi-concept frailty and the risk of cognitive disorders. This study aims to summarize the evidence of associations between multi-concept frailty and cognitive disorders based on longitudinal studies. Methods: Scopus, The Cochrane Library, PsycINFO, CINAHL, PubMed, and EMBASE databases were searched from inception to January 2, 2022. Longitudinal studies, which explored the association of frailty with incident risk of cognitive decline or dementia, were included. The multivariable-adjusted effect estimates were pooled by random-effects models. The evidence credibility was depicted according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. Results: A total of 30 longitudinal studies were included. Four types of frailty concepts were involved, including physical, cognitive, social, and biopsychosocial frailty. The meta-analysis comprised 20 studies of 252,571 older adults (mean age: 64.1-80.4 years), among whom 7,388 participants developed cognitive decline or dementia. Physical frailty was associated with higher risk of developing cognitive disorders [pooled relative risk (pRR) = 1.52, 95% confidence interval (CI): 1.28-1.80, Conclusion: Frailty in late life is a promising risk factor for cognitive disorders. Frail elderly should be monitored for their cognitive dynamics and initiate early prevention of dementia. Systematic Review Registration: www.ClinicalTrials.gov, identifier CRD4202127 3434.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.