Evidence map›Paper›PMID 35645559›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2022

Association between Inhaled β

Joseph Emil Amegadzie, John-Michael Gamble, Jamie Farrell, Zhiwei Gao

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Implication of Central βArchiv der Pharmazie · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. High use of short-acting βERJ open research · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Joseph Emil AmegadzieFaculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.ORCID 0000-0002-0459-7241
John-Michael GambleFaculty of Science, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0001-6891-8721
Jamie FarrellFaculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.ORCID 0000-0002-1719-8477
Zhiwei GaoFaculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.ORCID 0000-0002-5313-4884
Memorial University of Newfoundland · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Despite ample evidence underpinning the efficacy of β Methods: A nested case-control analysis was conducted using the UK Clinical Practice Research Datalink of patients with asthma, COPD or asthma-COPD overlap with initial treatment of LABA, SABA, ICS/LABA, ICS, long-or short-acting muscarinic antagonist (LAMA or SAMA) between 01 January 1998 and 31 July 2018. The primary outcome was MACE, defined as the first occurrence of stroke, heart failure, myocardial infarction, arrhythmia, or cardiovascular death. Each case was matched with up to 10 controls on age, sex, date of cohort-entry, and duration of follow-up. The risk of MACE associated with β Results: The cohort included 180,567 new users of β Conclusion: In conclusion, initiation of LABA, SABA, or ICS/LABA in COPD or SABA in asthma-COPD overlap is associated with increased risk of MACE. No associations were observed among patients with asthma.

Indexed as

AsthmaCardiovascular DiseasesPulmonary Disease, Chronic ObstructiveAdministration, InhalationAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsCase-Control StudiesHumansAdrenergic beta-2 Receptor AgonistsBronchodilator Agentsasthmachronic obstructive pulmonary diseasenested case–control

Identifiers

PMID35645559
PMCPMC9130098
OpenAlexW4280515431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.