ReviewBiomarker insights2022
Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review.
Review in Biomarker insights, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review.Integrative cancer therapiesPooled it
- A prospective trial for breast cancer diagnosis by canine odorology.Nature communications · 2025Trial
- Article
- Breathprints for Breast Cancer: Evaluating a Non-Invasive Approach to BI-RADS 4 Risk Stratification in a Preliminary Study.Cancers · 2026Article
- Preliminary Descriptive Study on the Conservation of Human Sweat Odor: Impact of Storage Temperature and Duration on the Stability of Volatile Organic Compounds in Sorbent Samples.International journal of analytical chemistry · 2026Article
- High-TMR iron-free double-barrier MTJs with MoTeRSC advances · 2025Article
- Explorative Detection of Fractional Exhaled Nitric Oxide (FeNO) in Exhaled Breath of Patients With Breast Cancer.Cancer medicine · 2025Article
- An engineered culture vessel and flow system to improve the in vitro analysis of volatile organic compounds.Communications engineering · 2025Article
- Innovative Approaches to Early Detection of Cancer-Transforming Screening for Breast, Lung, and Hard-to-Screen Cancers.Cancers · 2025Review
- Online monitoring and stable isotope tracing of cancer associated volatiles in murine model captures tumor associated markers in vivo.Analytica chimica acta · 2025Article
- Article
- Machine learning assisted breathomic approach for early-stage thoracic cancer detection.Frontiers in oncology · 2025Article
- Metabolomics in cancer detection: A review of techniques, biomarkers, and clinical utility.BioMedicine · 2025Review
- Can dogs sniff out cancer? Exploring the role of medical detection dogs in Hong Kong's early diagnosis strategies.Frontiers in medicine · 2025Article
- A Comprehensive Review of Biomarker Sensors for a Breathalyzer Platform.Sensors (Basel, Switzerland) · 2024Review
- A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.Journal of breath research · 2023Article
- Selectivity of Exhaled Breath Biomarkers of Lung Cancer in Relation to Cancer of Other Localizations.International journal of molecular sciences · 2023Article
- Article
- Technology Roadmap for Flexible Sensors.ACS nano · 2023Review
- Fecal Volatile Metabolomics Predict Gram-Negative Late-Onset Sepsis in Preterm Infants: A Nationwide Case-Control Study.Microorganisms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: An early diagnosis is crucial in reducing mortality among people who have breast cancer (BC). There is a shortfall of characteristic early clinical symptoms in BC patients, highlighting the importance of investigating new methods for its early detection. A promising novel approach is the analysis of volatile organic compounds (VOCs) produced and emitted through the metabolism of cancer cells. Methods: The purpose of this systematic review is to outline the published research regarding BC-associated VOCs. For this, headspace analysis of VOCs was explored in patient-derived body fluids, animal model-derived fluids, and BC cell lines to identify BC-specific VOCs. A systematic search in PubMed and Web of Science databases was conducted according to the PRISMA guidelines. Results: Thirty-two studies met the criteria for inclusion in this review. Results highlight that VOC analysis can be promising as a potential novel screening tool. However, results of Discussion: Discrepant VOC results among BC studies have been obtained, highly due to methodological discrepancies. Therefore, methodological issues leading to disparities have been reviewed and recommendations have been made on the standardisation of VOC collection and analysis methods for BC screening, thereby improving future VOC clinical validation studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.