Evidence map›Paper›PMID 35645400›Full record

ArticleTomography (Ann Arbor, Mich.)2022

Imaging of Transmetallation and Chelation Phenomena Involving Radiological Contrast Agents in Mineral-Rich Fruits.

Subhendra Sarkar, Zoya Vinokur, Bleidis Buitrago, Lin Mousa, Hayley Sanchez, Analia Basilicata, Jodi-Ann Douglas, Seanetta Reddock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Subhendra SarkarDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.ORCID 0000-0002-5942-2801
Zoya VinokurDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.ORCID 0000-0002-0971-4726
Bleidis BuitragoDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.ORCID 0000-0001-5160-1998
Lin MousaDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.
Hayley SanchezDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.
Analia BasilicataDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.
Jodi-Ann DouglasDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.
Seanetta ReddockDepartment of Radiologic Technology & Medical Imaging, New York City College of Technology, City University of New York, New York, NY 11201, USA.
City University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exogenous heavy metals or non-metallic waste products, for example lanthanide or iodinated contrast media for radiological procedures, may interfere with the biochemical pools in patients and in common food sources, creating an excess buildup of exogenous compounds which may reach toxic levels. Although the mechanisms are unknown, our experiments were designed to test if this toxicity can be attributed to "transmetallation" or "chelation" reactions freeing up lanthanides or chelated transition metals in acidic fruits used as phantoms representing the biologically active and mineral-rich carbohydrate matrix. The rapid breakdown of stable contrast agents have been reported at a lower pH. The interaction of such agents with native metals was examined by direct imaging of contrast infused fresh apples and sweet potatoes using low energy X-rays (40-44 kVp) and by magnetic resonance imaging at 1.5 and 3T. The stability of the exogenous agents seemed to depend on endogenous counterions and biometals in these fruits. Proton spin echo MR intensity is sensitive to paramagnetic minerals and low energy X-ray photons are sensitively absorbed by photoelectric effects in all abundant minerals and were compared before and after the infusion of radiologic contrasts. Endogenous iron and manganese are believed to accumulate due to interactions with exogenous iodine and gadolinium in and around the infusion spots. X-ray imaging had lower sensitivity (detection limit approximately 1 part in 10

Indexed as

Contrast MediaLanthanoid Series ElementsChelating AgentsFruitHumansIonsMineralsRadiographyChelating AgentsContrast MediaIonsLanthanoid Series ElementsMineralschelationcontrast induced toxicityenvironmental pollutionenvironmental toxinsgadoliniumGBCAiodinated contrastmagnetic resonance imagingmammographic soft X-rayradiological contrast mediaT1 and T2 relaxationstransmetallationX-ray

Identifiers

PMID35645400
PMCPMC9149805
OpenAlexW4281554508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.