Evidence map›Paper›PMID 35645300›Full record

ReviewJournal of functional morphology and kinesiology2022

Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases.

Roberto Bonanni, Ida Cariati, Umberto Tarantino, Giovanna D'Arcangelo, Virginia Tancredi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of functional morphology and kinesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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  19. Therapeutic Mechanisms of Exercise in Parkinson's Disease.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Roberto BonanniDepartment of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, 00133 Rome, Italy.ORCID 0000-0002-7174-0714
Ida CariatiDepartment of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, 00133 Rome, Italy.ORCID 0000-0002-2102-5034
Umberto TarantinoDepartment of Clinical Sciences and Translational Medicine, "Tor Vergata" University of Rome, 00133 Rome, Italy.ORCID 0000-0003-0330-2189
Giovanna D'ArcangeloCentre of Space Bio-Medicine, "Tor Vergata" University of Rome, 00133 Rome, Italy.ORCID 0000-0002-2105-0395
Virginia TancrediCentre of Space Bio-Medicine, "Tor Vergata" University of Rome, 00133 Rome, Italy.ORCID 0000-0003-4779-2212
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientific evidence has demonstrated the power of physical exercise in the prevention and treatment of numerous chronic and/or age-related diseases, such as musculoskeletal, metabolic, and cardiovascular disorders. In addition, regular exercise is known to play a key role in the context of neurodegenerative diseases, as it helps to reduce the risk of their onset and counteracts their progression. However, the underlying molecular mechanisms have not yet been fully elucidated. In this regard, neurotrophins, such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glia cell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), have been suggested as key mediators of brain health benefits, as they are involved in neurogenesis, neuronal survival, and synaptic plasticity. The production of these neurotrophic factors, known to be increased by physical exercise, is downregulated in neurodegenerative disorders, suggesting their fundamental importance in maintaining brain health. However, the mechanism by which physical exercise promotes the production of neurotrophins remains to be understood, posing limits on their use for the development of potential therapeutic strategies for the treatment of neurodegenerative diseases. In this literature review, we analyzed the most recent evidence regarding the relationship between physical exercise, neurotrophins, and brain health, providing an overview of their involvement in the onset and progression of neurodegeneration.

Indexed as

brain healthneurodegenerationneuroprotectionneurotrophinsphysical exercisepreventive strategysynaptic plasticity

Identifiers

PMID35645300
PMCPMC9149968
OpenAlexW4225137412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.