Evidence map›Paper›PMID 35644933›Full record

ReviewClinical endocrinology2023

Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?

Sanja Medenica, Maria Elena Spoltore, Paulina Ormazabal, Ljiljana V Marina, Antoan Stefan Sojat, Antongiulio Faggiano, Lucio Gnessi, Rossella Mazzilli, Mikiko Watanabe

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  6. Weight management in women of reproductive age.Obesity and endocrinology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Sanja MedenicaDepartment of Internal Medicine, Endocrinology Section, Clinical Center of Montenegro,  Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
Maria Elena SpoltoreDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
Paulina OrmazabalInstitute of Health Sciences, Universidad de O'Higgins, Rancagua, Chile.
Ljiljana V MarinaDepartment for Obesity, Metabolic and Reproductive Disorders, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-2664-3664
Antoan Stefan SojatDepartment for Obesity, Metabolic and Reproductive Disorders, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, Serbia.
Antongiulio FaggianoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, AOU Sant'Andrea, Rome, Italy.
Lucio GnessiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.
Rossella MazzilliDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, AOU Sant'Andrea, Rome, Italy.ORCID 0000-0001-6707-3413
Mikiko WatanabeDepartment of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-2225-8814
Sapienza University of Rome · ITAzienda Ospedaliera Sant'Andrea · ITCenter for Health, Exercise and Sport Sciences · RSUniversity of Belgrade · RSUniversity of Montenegro · MEUniversity of O'Higgins · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low-grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state-of-the-art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment.

Indexed as

Infertility, FemalePolycystic Ovary SyndromeFemaleFertilityFertilization in VitroHumansObesityPandemicsassisted reproductive technologybody mass indexin vitro fertilizationmiscarriageoverweightpolycystic ovary syndromepregnancy

Identifiers

PMID35644933
PMCPMC10084349
OpenAlexW4282000804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.