Evidence map›Paper›PMID 35644889›Full record

ArticlePediatric obesity2022

Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study.

Angela Titmuss, Danielle K Longmore, Federica Barzi, Elizabeth L M Barr, Vanya Webster, Anna Wood, Alison Simmonds, Alex D H Brown, Christine Connors, Jacqueline A Boyle and 6 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06993103 (A Randomised Controlled Trial of Pasteurised Donor Human Milk as Supplementary Nutrition for Infants Born to Women With Diabetes in Pregnancy.), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06993103 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomised Controlled Trial of Pasteurised Donor Human Milk as Supplementary Nutrition for Infants Born to Women With Diabetes in Pregnancy.

TypeinterventionalSponsorThe University of QueenslandRan2025 to 2028Enrolled1,444ConditionsNeonatal Hypoglycemia, Metabolic Complication, Cows Milk Allergy, Hospital Length of StayArmsStandard care Cow's milk based formula, Dietary Supplement: PDHM Pasteurised Donor Human Milk
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
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  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Angela TitmussWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0002-9865-1252
Danielle K LongmoreWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0002-6232-8947
Federica BarziWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Elizabeth L M BarrWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Vanya WebsterWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Anna WoodWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Alison SimmondsWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Alex D H BrownWardliparingga Aboriginal Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Christine ConnorsTop End Health Service, Northern Territory Department of Health, Darwin, Northern Territory, Australia.
Jacqueline A BoyleWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Jeremy OatsMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
H David McIntyreFaculty of Medicine, Mater Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Jonathan E ShawClinical and Population Health, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Maria E CraigSchool of Women and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Louise J Maple-BrownWellbeing and Preventable Chronic Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
PANDORA Study Research Team
Charles Darwin University · AUBaker Heart and Diabetes Institute · AUThe University of Queensland · AUNorthern Territory Health Services · AUSouth Australian Health and Medical Research Institute · AUThe University of Melbourne · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have assessed whether children exposed to in utero hyperglycaemia experience different growth trajectories compared to unexposed children.

objectivesTo assess association of type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) with early childhood weight, length/height and body mass index (BMI) trajectories, and with timing and magnitude of peak BMI in infancy.

methodsPANDORA is a birth cohort recruited from an Australian hyperglycaemia in pregnancy register, and women with normoglycaemia recruited from the community. Offspring growth measures were obtained from health records over a median follow-up of 3.0 years (interquartile range 1.9-4.0). This analysis included children born to Aboriginal mothers with in utero normoglycaemia (n = 95), GDM (n = 228) or T2D (n = 131). Growth trajectories (weight, length/height and BMI) were estimated using linear mixed models with cubic spline functions of child age.

resultsAfter adjustment for maternal factors (age, BMI, parity, smoking, and socioeconomic measures) and child factors (age, gestational age at birth, and sex), children born to mothers with T2D or GDM had lower weight, length/height and BMI trajectories in infancy than children born to mothers with normoglycaemia, but similar weight and BMI by completion of follow-up. Children exposed to T2D had lower mean peak BMI 17.6 kg/m

conclusionsMaternal hyperglycaemia was associated with differences in early childhood growth trajectories after adjustment for maternal BMI. Exploration of associations between in utero hyperglycaemia exposure and growth trajectories into later childhood is required.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2HyperglycemiaAustraliaBirth WeightBody Mass IndexChildChild, PreschoolFemaleHumansInfant, NewbornPregnancyRisk FactorsAboriginalchilddiabetesgrowthpregnancy

Identifiers

PMID35644889
PMCPMC9539556
OpenAlexW4281742241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.