Evidence map›Paper›PMID 35644722›Full record

ArticleNeuromuscular disorders : NMD2022

Bilateral facial palsy with paresthesias, variant of Guillain-Barré syndrome following COVID-19 vaccine: A case series of 9 patients.

J I Castiglione, J M Crespo, L Lecchini, F O Silveira, M B Luis, N Cotti, C J Simison, F Aguirre, M A Piedrabuena, R N Alonso and 4 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neuromuscular disorders : NMD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  11. Association of Guillain-Barré syndrome following COVID-19 vaccination.International journal of immunopathology and pharmacology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

J I CastiglioneNeurology Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, Buenos Aires 1428, Argentina. Electronic address: jicastiglione@fleni.org.ar.
J M CrespoNeurology Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, Buenos Aires 1428, Argentina; Hospital Nacional Alejandro Posadas, Argentina; Hospital Italiano de Buenos Aires, Argentina; Sanatorio Güemes, Argentina.
L LecchiniHospital Nacional Alejandro Posadas, Argentina.
F O SilveiraHospital Italiano de Buenos Aires, Argentina.
M B LuisSanatorio Güemes, Argentina.
N CottiSanatorio de los Arcos, Argentina.
C J SimisonHospital J.M. Ramos Mejía, Argentina.
F AguirreHospital J.M. Ramos Mejía, Argentina.
M A PiedrabuenaSanatorio de los Arcos, Argentina.
R N AlonsoSanatorio Güemes, Argentina.
C L AzconaHospital Italiano de Buenos Aires, Argentina.
P S SosaHospital Italiano de Buenos Aires, Argentina.
E MaldonadoHospital Nacional Alejandro Posadas, Argentina.
F BarrosoNeurology Department, Raul Carrea Institute for Neurological Research (FLENI), Montañeses 2325, Buenos Aires 1428, Argentina.
Hospital Italiano de Buenos Aires · ARFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · ARHelios Salud · ARHospital Posadas · ARHospital Ramos Mejía · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several cases of Guillain-Barré Syndrome (GBS) associated with COVID-19 vaccination have been reported, including the rare subtype known as Bilateral Facial Palsy with paresthesias (BFP). To date, it is not known whether a causal relationship may exist between the two. We report 9 cases of BFP in patients vaccinated against COVID-19 in the previous month. Nerve conduction studies revealed demyelinating polyneuropathy in 4 patients, and 5 presented bilateral, focal facial nerve involvement, exclusively. Ganglioside antibody panel was positive in 4 patients (anti-GM1=2, anti-GD1a=1 and anti-sulfatide=1). Seven patients received intravenous immunoglobulin treatment, one plasma exchange, and one patient died from sudden cardiac arrest following arrhythmia before treatment could be administered. Rates of BFP following COVID-19 vaccination, did not differ from those reported in previous series. Epidemiological studies are essential to determine whether a causal relationship may exist between this rare form of GBS and COVID-19 vaccination.

Indexed as

COVID-19 VaccinesFacial ParalysisGuillain-Barre SyndromeParesthesiaCOVID-19HumansCOVID-19 VaccinesBilateral Facial Palsy (BFP)COVID-19 vaccineFacial diplegiaGuillain-Barré Syndrome (GBS)

Identifiers

PMID35644722
PMCPMC9090822
OpenAlexW4280624388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.