ArticleClinical immunology (Orlando, Fla.)2022
T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice.
Open access · greenAbstract read
In one paragraph
Article in Clinical immunology (Orlando, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo.JCI insight · 2026Article
- Advancement of humanized mice and leading applications in immunological disease models.Inflammation and regeneration · 2026Review
- Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative.Diabetes · 2025Review
- T Cell Development and Responses in Human Immune System Mice.Annual review of immunology · 2025Review
- Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- B cell development and antibody responses in human immune system mice: current status and future perspective.Science China. Life sciences · 2024Review
- Review
- T follicular helper cells and T follicular regulatory cells in autoimmune diseases.Frontiers in immunology · 2023Review
- Identification of biomarkers associated with immune scores in diabetic retinopathy.Frontiers in endocrinology · 2023Article
- Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Andrea VecchioneColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA; San Raffaele Hospital, Via Olgettina, 58, 20132 Milan, Italy. Electronic address: andrevecc@gmail.com.
Rachel MadleyColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA.
Nichole DanzlColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA. Electronic address: nmd2101@cumc.columbia.edu.
Chiara BorsottiColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA. Electronic address: chiara.borsotti@uniupo.it.
Mohsen Khosravi MarharlooeiColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA. Electronic address: mkm2182@cumc.columbia.edu.
Hao-Wei LiColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA. Electronic address: hl2591@cumc.columbia.edu.
Grace NaumanColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY, USA.
Xiaolan DingColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA. Electronic address: xd2150@cumc.columbia.edu.
Siu-Hong HoColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA.
Georgia FousteriSan Raffaele Hospital, Via Olgettina, 58, 20132 Milan, Italy. Electronic address: fousteri.georgia@hsr.it.
Megan SykesColumbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, 650 West 168th St, BB1512 New York, NY, USA; Department of Microbiology and Immunology, Columbia University Medical Center, Columbia University, New York, NY, USA; Department of Surgery, Columbia University Medical Center, Columbia University, New York, NY, USA. Electronic address: ms3976@cumc.columbia.edu.
Columbia University Irving Medical Center · US
Funding
XENOGRAFT TOLERANCE THROUGH MIXED CHIMERISMP01AI045897 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Megan Sykes · 2000 to 2026
$71.9MTranslational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anthony W Ferrante · 2003 to 2026
$36.7MModeling autoimmune pathogenesis and beta cell destruction by T1D immune systemsU01DK123559 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDERSON, MARK S, PARENT, AUDREY · 2019 to 2023
$4.3MMice with autologous human T1D-derived immune systems and iPSC-derived beta cellsUC4DK104207 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2014 to 2014
$3.8MImmune Response to iPSC-Derived Beta Cells in Type 1 DiabetesR01DK103585 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2015 to 2018
$1.8MThymic negative selection in human T1D immune systemsR21AI146828 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2019 to 2020
$437kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kNCRR NIH HHS S10 RR027050NIAID NIH HHS P01 AI045897NIAID NIH HHS R21 AI146828NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R01 DK103585NIDDK NIH HHS U01 DK123559NIDDK NIH HHS UC4 DK104207
Abstract
Interactions between B cells and CD4
Indexed as
B-Lymphocyte SubsetsDiabetes Mellitus, Type 1AnimalsAutoimmunityHematopoietic Stem CellsHumansMiceT Follicular Helper CellsT-Lymphocytes, Helper-InducerAutoantibodiesAutoimmunityAutoreactiveB cellHematopoietic stem cellsHuman immune system micePersonalized immune miceT helper follicular cellT peripheral helper cellType 1 diabetes
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.