Evidence map›Paper›PMID 35644126›Full record

ReviewEBioMedicine2022

Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes.

Yihang Han, Di Wu, Yanjuan Wang, Jian Xie, Zhijun Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Peripheral proteinopathy in neurodegenerative diseases.Translational neurodegeneration · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Refining the clinical diagnosis of Parkinson's disease.Parkinsonism & related disorders · 2024
    Review
  16. Review
  17. Getting to the heart of Lewy body disease.The Journal of clinical investigation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yihang HanDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, China.
Di WuDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, China.
Yanjuan WangDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, China.
Jian XieDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, China.
Zhijun ZhangDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, China. Electronic address: janemengzhang@vip.163.com.
Zhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by the formation of Lewy bodies comprised mainly of α-synuclein. Assessment of skin synuclein has the potential as an excellent diagnostic method with high sensitivity, specificity, and reproducibility that is also convenient and acceptable to patients. In this review, we summarize findings regarding the characteristics of cutaneous nerve p-α-syn or α-syn deposits and their correlations with clinical phenotypes in PD patients with and without orthostatic hypotension and LRRK2, GBA, and SNCA gene mutations. This review can serve as a reference for the diagnosis and classification of PD based on α-syn deposit patterns and to deeply explore its pathogenesis. FUNDING STATEMENT: The work was partly supported by the National Natural Science Key Foundation of China (No. 81830040 and No 82130042) and the Program of Excellent Talents in Medical Science of Jiangsu Province (No. JCRCA2016006) .

Indexed as

Neurodegenerative DiseasesParkinson Diseasealpha-SynucleinGene ExpressionHumansReproducibility of Resultsalpha-SynucleinAlpha-synucleinAutonomic dysfunctionGBALRRK2Parkinson's diseaseSNCA

Identifiers

PMID35644126
PMCPMC9148991
OpenAlexW4281570780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.