Evidence map›Paper›PMID 35644101›Full record

ArticleESMO open2022

COVID-19 in patients with cancer: first report of the ESMO international, registry-based, cohort study (ESMO-CoCARE).

L Castelo-Branco, Z Tsourti, S Gennatas, J Rogado, M Sekacheva, D Viñal, R Lee, A Croitoru, M Vitorino, S Khallaf and 18 more

Open access · goldAbstract read
In one paragraph

Article in ESMO open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Remdesivir-Associated Survival Outcomes Among Immunocompromised Patients Hospitalized for COVID-19: Real-world Evidence From the Omicron-Dominant Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 16 countries.

L Castelo-BrancoScientific and Medical Division, ESMO (European Society for Medical Oncology), Lugano, Switzerland; NOVA National School of Public Health, NOVA University, Lisbon, Portugal.
Z TsourtiFrontier Science Foundation-Hellas, Athens, Greece.
S GennatasMedical Oncology Department, The Royal Marsden Hospital - NHS Foundation Trust, London, UK.
J RogadoMedical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.
M SekachevaWorld-Class Research Center 'Digital Biodesign and Personalized Healthcare', Sechenov First Moscow State Medical University, Moscow, Russia.
D ViñalMedical Oncology Department, Hospital Universitario La Paz, Madrid, Spain.
R LeeMedical Oncology Department, The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.
A CroitoruMedical Oncology Department, Fundeni Clinical Institute, Bucharest, Romania.
M VitorinoServico Oncologia, Hospital Prof. Dr Fernando Fonseca EPE (Hospital Amadora/Sintra), Amadora, Portugal.
S KhallafMedical Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, Assiut, Egypt.
S ŠušnjarDepartment of Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
W SoewotoDepartment of Surgery, Oncology Division, Sebelas Maret University, Surakarta, Indonesia.
A CardeñaMedical Oncology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
M DjerouniOncology Department, Dr Saadane Hospital, Biskra, Algeria.
M RossiOncology Deparment, ASO 'SS. Antonio, Biagio e Cesare Arrigo', Alessandria, Italy.
T Alonso-GordoaMedical Oncology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
C NgelangelAsian Cancer Institute - Asian Hospital and Medical Center, Metro Manila, the Philippines.
J G WhisenantVanderbilt University Medical Center, Nashville, USA.
T K ChoueiriThe Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, USA; Harvard Medical School, Boston, USA.
G DimopoulouFrontier Science Foundation-Hellas, Athens, Greece.
S PradervandOncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
D ArnoldOncology, Haematology, Palliative Care Department, Asklepios Klinik Altona - Asklepios Kliniken, Hamburg, Germany.
K HarringtonDivision of Radiotherapy and Imaging, The Royal Marsden/The Institute of Cancer Research NIHR Biomedical Research Centre, London, UK.
O MichielinOncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
U DafniLaboratory of Biostatistics, School of Health Sciences, National and Kapodistrian University of Athens, Athens Frontier Science Foundation-Hellas, Athens, Greece.
G PentheroudakisScientific and Medical Division, ESMO (European Society for Medical Oncology), Lugano, Switzerland.
S PetersDepartment, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
E RomanoCenter for Cancer Immunotherapy, Department of Oncology, PSL Research University, Institut Curie, Paris, France. Electronic address: emanuela.romano@curie.fr.
Frontier Science Foundation-Hellas · GRUniversity Hospital of Lausanne · CHEuropean Society for Medical Oncology · CHAsian Hospital and Medical Center · PHAsklepios Klinik Altona · DEAssiut University · EGAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITBoston University · USHospital Prof. Dr. Fernando Fonseca · PTHospital Universitario Fundación Alcorcón · ESHospital Universitario Infanta Leonor · ESHospital Universitario La Paz · ESHospital Universitario Ramón y Cajal · ESInstitut Curie · FRInstitute of Cancer Research · GBInstitutul Clinic Fundeni · ROOncology Institute of Vojvodina · RSRoyal Marsden Hospital · GBSebelas Maret University · IDSechenov University · RU

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI David McDermott · 2003 to 2026
$53.4M
NCI NIH HHS P30 CA006516NCI NIH HHS P50 CA101942
6 · The paper itself

Abstract

backgroundESMO COVID-19 and CAncer REgistry (ESMO-CoCARE) is an international collaborative registry-based, cohort study gathering real-world data from Europe, Asia/Oceania and Africa on the natural history, management and outcomes of patients with cancer infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). PATIENTS AND

methodsESMO-CoCARE captures information on patients with solid/haematological malignancies, diagnosed with coronavirus disease 2019 (COVID-19). Data collected since June 2020 include demographics, comorbidities, laboratory measurements, cancer characteristics, COVID-19 clinical features, management and outcome. Parameters influencing COVID-19 severity/recovery were investigated as well as factors associated with overall survival (OS) upon SARS-CoV-2 infection.

resultsThis analysis includes 1626 patients from 20 countries (87% from 24 European, 7% from 5 North African, 6% from 8 Asian/Oceanian centres), with COVID-19 diagnosis from January 2020 to May 2021. Median age was 64 years, with 52% of female, 57% of cancer stage III/IV and 65% receiving active cancer treatment. Nearly 64% patients required hospitalization due to COVID-19 diagnosis, with 11% receiving intensive care. In multivariable analysis, male sex, older age, Eastern Cooperative Oncology Group (ECOG) performance status ≥2, body mass index (BMI) <25 kg/m

conclusionsSelected patient and cancer characteristics related to sex, ethnicity, poor fitness, comorbidities, inflammation and active malignancy predict for severe/moderate disease and adverse outcomes from COVID-19 in patients with cancer.

Indexed as

COVID-19Hematologic NeoplasmsNeoplasmsCohort StudiesCOVID-19 TestingFemaleHumansMaleMiddle AgedRegistriesSARS-CoV-2cancerCOVID-19oncologySARS-CoV-2

Identifiers

PMID35644101
PMCPMC9080222
OpenAlexW4229332259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.