Evidence map›Paper›PMID 35644039›Full record

ArticleJournal of applied clinical medical physics2022

Treatment planning system commissioning of the first clinical biology-guided radiotherapy machine.

Eric Simiele, Dante Capaldi, Dylan Breitkreutz, Bin Han, Timothy Yeung, John White, Daniel Zaks, Michael Owens, Srinath Maganti, Lei Xing and 2 more

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Preclinical Evaluation ofInternational journal of radiation oncology, biology, physics · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eric SimieleDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Dante CapaldiDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Dylan BreitkreutzDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Bin HanDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Timothy YeungRefleXion Medical, Inc., Hayward, California, USA.
John WhiteRefleXion Medical, Inc., Hayward, California, USA.
Daniel ZaksRefleXion Medical, Inc., Hayward, California, USA.
Michael OwensRefleXion Medical, Inc., Hayward, California, USA.
Srinath MagantiRefleXion Medical, Inc., Hayward, California, USA.
Lei XingDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Murat SurucuDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Nataliya KovalchukDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe RefleXion X1 is a novel radiotherapy machine designed for image-guided radiotherapy (IGRT) and biology-guided radiotherapy (BgRT). Its treatment planning system (TPS) generates IMRT and SBRT plans for a 6MV-FFF beam delivered axially via 50 firing positions with the couch advancing every 2.1 mm. The purpose of this work is to report the TPS commissioning results for the first clinical installation of RefleXion™ X1.

methodsCT images of multiple phantoms were imported into the RefleXion TPS to evaluate the accuracy of data transfer, anatomical modeling, plan evaluation, and dose calculation. Comparisons were made between the X1, Eclipse™, and MIM™. Dosimetric parameters for open static fields were evaluated in water and heterogeneous slab phantoms. Representative clinical IMRT and SBRT cases were planned and verified with ion chamber, film, and ArcCHECK

resultsThe average difference between the TPS-reported and known HU values was -1.4 ± 6.0 HU. For static fields, the agreements between the TPS-calculated and measured PDD

conclusionsThe TPS commissioning results of the RefleXion X1 TPS were within the tolerances specified by AAPM TG 53, MPPG 5.a, TG 119, and TG 148. A subset of the commissioning tests has been identified as baseline data for an ongoing QA program.

Indexed as

Radiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedBiologyHumansPhantoms, ImagingRadiometryRadiotherapy DosageBgRTRefleXionTPS commissioning

Identifiers

PMID35644039
PMCPMC9359035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.