SynthesisArthritis & rheumatology (Hoboken, N.J.)2022
Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores.
Synthesis in Arthritis & rheumatology (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.Human molecular genetics · 2025Pooled it
- Article
- Social and Demographic Health Disparities in Knee Osteoarthritis and Total Knee Arthroplasty.Arthroplasty today · 2026Review
- Polygenic risk and air pollution trends in relation to type 2 diabetes: evidence from the Taiwan Biobank.Diabetology & metabolic syndrome · 2026Article
- Translating Osteoarthritis Genetic Risk Into Biomarkers: Opportunities, Pitfalls, and Implementation Considerations.Human mutation · 2026Review
- Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review.Journal of hip preservation surgery · 2025Review
- Dissect Gender-Dependent Susceptibility SNPs in Progressive Osteoarthritis Using Regulator Motif Candidate of Genetic Association Strategy (RMCGA).International journal of molecular sciences · 2025Article
- Integrating the environmental and genetic architectures of aging and mortality.Nature medicine · 2025Article
- Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.PloS one · 2025Article
- Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis.Frontiers in immunology · 2025Article
- Follow-up of GSTM1, GSTT1, and NAT2 genotyped patients with knee or hip replacement.EXCLI journal · 2025Article
- Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.Aging and disease · 2024Review
- Genomic heterozygosity is associated with a lower risk of osteoarthritis.BMC genomics · 2024Article
- Review
- The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis.International journal of molecular sciences · 2023Review
- Genetic risk of osteoarthritis operates during human skeletogenesis.Human molecular genetics · 2023Article
- Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.Arthritis research & therapy · 2023Article
- Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression.American journal of physiology. Cell physiology · 2023Review
- Toward Precision Medicine-Is Genetic Risk Prediction Ready for Prime Time in Osteoarthritis?Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePolygenic risk scores (PRS) allow risk stratification using common single-nucleotide polymorphisms (SNPs), and clinical applications are currently explored for several diseases. This study was undertaken to assess the risk of hip and knee osteoarthritis (OA) using PRS.
methodsWe analyzed 12,732 individuals from a population-based cohort from the Rotterdam Study (n = 11,496), a clinical cohort (Cohort Hip and Cohort Knee [CHECK] study; n = 908), and a high-risk cohort of overweight women (Prevention of Knee OA in Overweight Females [PROOF] study; n = 328), for the association of the PRS with prevalence/incidence of radiographic OA, of clinical OA, and of total hip replacement (THR) or total knee replacement (TKR). The hip PRS and knee PRS contained 44 and 24 independent SNPs, respectively, and were derived from a recent genome-wide association study meta-analysis. Standardized PRS (with Z transformation) were used in all analyses.
resultsWe found a stronger association of the PRS for clinically defined OA compared to radiographic OA phenotypes, and we observed the highest PRS risk stratification for TKR/THR. The odds ratio (OR) per SD was 1.3 for incident THR (95% confidence interval [95% CI] 1.1-1.5) and 1.6 (95% CI 1.3-1.9) for incident TKR in the Rotterdam Study. The knee PRS was associated with incident clinical knee OA in the CHECK study (OR 1.3 [95% CI 1.1-1.5]), but not for the PROOF study (OR 1.2 [95% CI 0.8-1.7]). The OR for OA increased gradually across the PRS distribution, up to 2.1 (95% CI 1.4-3.2) for individuals with the 10% highest PRS compared to the middle 50% of the PRS distribution.
conclusionOur findings validated the association of PRS across OA definitions. Since OA is becoming frequent and primary prevention is not commonly applicable, PRS-based risk assessment could play a role in OA prevention. However, the utility of PRS is dependent on the setting. Further studies are needed to test the integration of genetic risk assessment in diverse health care settings.
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