Evidence map›Paper›PMID 35643577›Full record

ArticleMicrobial cell factories2022

Carbon dioxide fixation via production of succinic acid from glycerol in engineered Saccharomyces cerevisiae.

Zahabiya Malubhoy, Frederico Mendonça Bahia, Sophie Claire de Valk, Erik de Hulster, Toni Rendulić, Juan Paulo Ragas Ortiz, Joeline Xiberras, Mathias Klein, Robert Mans, Elke Nevoigt

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Zahabiya MalubhoyDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Frederico Mendonça BahiaDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Sophie Claire de ValkDepartment of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
Erik de HulsterDepartment of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
Toni RendulićDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Juan Paulo Ragas OrtizDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Joeline XiberrasDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Mathias KleinDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany.
Robert MansDepartment of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
Elke NevoigtDepartment of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759, Bremen, Germany. e.nevoigt@jacobs-university.de.
Constructor University · DEDelft University of Technology · NL

Funding

Deutsche Forschungsgemeinschaft NE 697/7-1Horizon 2020 Framework Programme 764927
6 · The paper itself

Abstract

backgroundThe microbial production of succinic acid (SA) from renewable carbon sources via the reverse TCA (rTCA) pathway is a process potentially accompanied by net-fixation of carbon dioxide (CO

resultsBy changing the design of the expression cassettes for the rTCA pathway, overexpressing PYC2, and adding CaCO

conclusionsThe data strongly suggest that a major part of dicarboxylic acids in our 2nd-generation SA-producer was formed via the rTCA pathway enabling a net fixation of CO

Indexed as

Saccharomyces cerevisiaeSuccinic AcidBicarbonatesCarbon DioxideCulture MediaGlycerolGlyoxylatesBicarbonatesCarbon DioxideCulture MediaGlycerolGlyoxylatesSuccinic AcidCarbon dioxideCO2 fixingDicarboxylic acidsFermentationGlycerolMetabolic engineeringSaccharomyces cerevisiaeSuccinic acidYeast

Identifiers

PMID35643577
PMCPMC9148483
OpenAlexW4281753195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.