Evidence map›Paper›PMID 35643549›Full record

ReviewMicrobial cell factories2022

Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms.

Shriya Hans, Nilesh Kumar, Nisarg Gohil, Khushal Khambhati, Gargi Bhattacharjee, Shalini S Deb, Rupesh Maurya, Vinod Kumar, Shamlan M S Reshamwala, Vijai Singh

Open access · goldAbstract readReview
In one paragraph

Review in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Shriya HansMTech programme in Bioprocess Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India.
Nilesh KumarMTech programme in Bioprocess Technology, Institute of Chemical Technology, Mumbai, Maharashtra, 400019, India.
Nisarg GohilDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Khushal KhambhatiDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Gargi BhattacharjeeDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Shalini S DebDBT-ICT Centre for Energy Biosciences, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga (East), Mumbai, Maharashtra, 400019, India.
Rupesh MauryaDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India.
Vinod KumarCentre for Climate and Environmental Protection, School of Water, Energy and Environment, Cranfield University, Cranfield, MK43 0AL, UK.
Shamlan M S ReshamwalaDBT-ICT Centre for Energy Biosciences, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga (East), Mumbai, Maharashtra, 400019, India. ss.reshamwala@ictmumbai.edu.in.
Vijai SinghDepartment of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, 382715, India. vijaisingh15@gmail.com.
Indrashil University · INInstitute of Chemical Technology · INCranfield University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surging demand of value-added products has steered the transition of laboratory microbes to microbial cell factories (MCFs) for facilitating production of large quantities of important native and non-native biomolecules. This shift has been possible through rewiring and optimizing different biosynthetic pathways in microbes by exercising frameworks of metabolic engineering and synthetic biology principles. Advances in genome and metabolic engineering have provided a fillip to create novel biomolecules and produce non-natural molecules with multitude of applications. To this end, numerous MCFs have been developed and employed for production of non-natural nucleic acids, proteins and different metabolites to meet various therapeutic, biotechnological and industrial applications. The present review describes recent advances in production of non-natural amino acids, nucleic acids, biofuel candidates and platform chemicals.

Indexed as

Nucleic AcidsBiosynthetic PathwaysBiotechnologyMetabolic EngineeringSynthetic BiologyNucleic AcidsBiofuelsMetabolic engineeringMicrobial cell factoriesNon-canonical amino acidsNon-natural biomoleculesXeno nucleic acids

Identifiers

PMID35643549
PMCPMC9148472
OpenAlexW4281869392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.