Evidence map›Paper›PMID 35643540›Full record

ArticleJournal of neuroinflammation2022

Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people.

Christopher Clark, Jonas Richiardi, Bénédicte Maréchal, Gene L Bowman, Loïc Dayon, Julius Popp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  11. Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  12. Inflammaging and Brain Aging.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Christopher ClarkInstitute for Regenerative Medicine, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland. christopher.clark@irem.uzh.ch.
Jonas RichiardiDepartment of Radiology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
Bénédicte MaréchalAdvanced Clinical Imaging Technologies Group, Siemens Healthcare Switzerland, 1015, Lausanne, Switzerland.
Gene L BowmanNestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, Bâtiment H, 1015, Lausanne, Switzerland.
Loïc DayonNestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, Bâtiment H, 1015, Lausanne, Switzerland.
Julius PoppInstitute for Regenerative Medicine, University of Zürich, Wagistrasse 12, 8952, Schlieren, Switzerland. julius.popp@puk.zh.ch.ORCID http://orcid.org/0000-0002-0068-0312
University of Zurich · CHNational University of Natural Medicine · USNestlé (Switzerland) · CHSiemens (Switzerland) · CHUniversity of Lausanne · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung SNF 320030_141179Stiftung Synapsis - Alzheimer Forschung Schweiz AFS 2017-PI01
6 · The paper itself

Abstract

backgroundNeuroinflammation may contribute to psychiatric symptoms in older people, in particular in the context of Alzheimer's disease (AD). We sought to identify systemic and central nervous system (CNS) inflammatory alterations associated with neuropsychiatric symptoms (NPS); and to investigate their relationships with AD pathology and clinical disease progression.

methodsWe quantified a panel of 38 neuroinflammation and vascular injury markers in paired serum and cerebrospinal fluid (CSF) samples in a cohort of cognitively normal and impaired older subjects. We performed neuropsychiatric and cognitive evaluations and measured CSF biomarkers of AD pathology. Multivariate analysis determined serum and CSF neuroinflammatory alterations associated with NPS, considering cognitive status, AD pathology, and cognitive decline at follow-up visits.

resultsNPS were associated with distinct inflammatory profiles in serum, involving eotaxin-3, interleukin (IL)-6 and C-reactive protein (CRP); and in CSF, including soluble intracellular cell adhesion molecule-1 (sICAM-1), IL-8, 10-kDa interferon-γ-induced protein, and CRP. AD pathology interacted with CSF sICAM-1 in association with NPS. Presenting NPS was associated with subsequent cognitive decline which was mediated by CSF sICAM-1.

conclusionsDistinct systemic and CNS inflammatory processes are involved in the pathophysiology of NPS in older people. Neuroinflammation may explain the link between NPS and more rapid clinical disease progression.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedBiomarkersCentral Nervous SystemC-Reactive ProteinDisease ProgressionHumansInterleukin-6BiomarkersC-Reactive ProteinInterleukin-6Alzheimer’s disease, biomarkersCerebrospinal fluidCognitive declineNeuroinflammationNeuropsychiatric symptomsSerum

Identifiers

PMID35643540
PMCPMC9148517
OpenAlexW4281738003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.