ArticleBMC gastroenterology2022
The relationships between IBS and perceptions of physical and mental health-a Norwegian twin study.
Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Face-to-Face Versus Digital, Telephone-Delivered, and Self-Help Cognitive Behavioral Therapy for Irritable Bowel Syndrome: Systematic Review and Bayesian Indirect Treatment Comparison Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Physical and Mental Health as Biopsychosocial Correlates and Pathways Associated With Symptom Severity in Irritable Bowel Syndrome: A Cross-Sectional Structural Equation Modeling Study.Neurogastroenterology and motility · 2026Article
- Depressive symptoms as a mediator in the association between regular physical activity and irritable bowel syndrome-related symptom severity: a cross-sectional study among college students.Frontiers in psychology · 2026Article
- Comparative evaluation of gut health, inflammatory factors, and sleep quality among shift workers: A cross-sectional study.Journal of education and health promotion · 2026Article
- The diagnostic criteria for psychosomatic research-revised (DCPR-R) in a National China multicenter cohort of patients with irritable bowel syndrome and overlapping gastroesophageal reflux disease.BMC gastroenterology · 2025Article
- Parental Factors Associated to Functional Abdominal Pain Disorders in the Pediatric Age Group: A Case-Control Study.Advanced biomedical research · 2025Article
- Self-rated health and its bidirectional relationship with burnout, sleep quality and somatic symptoms in a general adult population.BMC public health · 2024Article
- Preliminary Validation of a General Factor Model of Chronic Overlapping Pain Conditions.The journal of pain · 2024Article
- Assessment of Self-Reported Executive Function in Patients with Irritable Bowel Syndrome Using a Machine-Learning Framework.Journal of clinical medicine · 2023Article
- Symptom management needs of patients with irritable bowel syndrome and concurrent anxiety and/or depression: A qualitative study.Journal of advanced nursing · 2023Article
- Psychological distress, perceived stress and nocebo effect (multifood adverse reaction) in irritable bowel syndrome patients.Journal of education and health promotion · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND AND
aimsPoor quality of life is a main complaint among individuals with irritable bowel syndrome (IBS). Self-rated health (SRH) is a powerful predictor of clinical outcomes, and also reflects psychological and social aspects of life and an overall sense of well-being. This population-based twin study evaluates how IBS affects ratings of physical and mental health, and influences perceptions of hindrance of daily activity by physical or mental health. Further, we examine how IBS is related to these SRH measures.
methodsThe sample included 5288 Norwegian twins aged 40-80, of whom 575 (10.9%) suffer from IBS. Hierarchical regressions were used to estimate the impact of IBS on perceptions of health, before and after accounting for other chronic physical and mental health conditions. Two dimensions of SRH, physical and mental, and two aspects of functional limitations, the extent to which physical or mental health interferes with daily activities, were included as outcomes in separate models. Co-twin control analyses were used to explore whether the relationships between IBS and the four measures of SRH are causal, or due to shared genetic or shared environment effects.
resultsIBS was an independent predictor of poor self-rated physical health (OR = 1.82 [1.41; 2.33]), the size of this effect was comparable to that predicted by chronic somatic conditions. However, in contrast to somatic diseases, IBS was associated with the perception that poorer ratings of mental health (OR = 1.45 [1.02; 2.06]), but not physical health (OR = 1.23 [0.96; 1.58]), interfered with daily activity. The co-twin control analyses suggest that causal mechanisms best explain the relationships between IBS with self-rated physical health and with hindrance of daily activities. In contrast, the relationship between IBS and self-rated mental health was consistent with shared genetic effects.
conclusionIBS is predictive of poor self-rated physical health. The relationship between IBS and self-rated mental health is best explained by shared genetic effects which might partially explain why mental health interferes with daily activity to a larger degree among those with IBS.
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