ArticleBMC geriatrics2022
Association of triglyceride glucose index with all-cause and cause-specific mortality among middle age and elderly US population.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association of triglyceride-glucose index with cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Association between triglyceride glucose index and risk of cancer: A meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Interplay between triglyceride-glucose index and cardiovascular events in hypertensive patients with controlled blood pressure (SBP<140 mmHg): insights from the SPRINT trial.Frontiers in endocrinology · 2025Trial
- Improving cardiovascular risk stratification through the derivation and validation of an elevated triglyceride-glucose index.Diabetes, obesity & metabolism · 2026Article
- Nonlinear Relationship Between the Triglyceride-Glucose Index and All-Cause and Cardiovascular Mortality in Diabetes Mellitus Patients With Hypertension: A National Cohort Study.International journal of endocrinology · 2026Article
- Triglyceride-glucose index, HOmeostatic Model Assessment index, and new-onset hypertension in middle-aged men.Journal of hypertension · 2026Article
- Combined association of triglyceride-glucose index and systemic inflammation index on all-cause and cardiovascular mortality.Scientific reports · 2025Article
- Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015).The Lancet regional health. Europe · 2025Article
- Association between triglyceride-glucose index and major adverse cardiovascular events in patients with intermediate coronary stenosis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Triglyceride-glucose index and clinical outcomes in sepsis: A retrospective cohort study of MIMIC-IV.Journal of cellular and molecular medicine · 2024Article
- Association of the triglyceride-glucose index with all-cause and cause-specific mortality: a population-based cohort study of 3.5 million adults in China.The Lancet regional health. Western Pacific · 2024Article
- Association between the triglyceride-glucose index and all-cause and CVD mortality in the young population with diabetes.Cardiovascular diabetology · 2024Article
- The impact of triglyceride glucose-body mass index on all-cause and cardiovascular mortality in elderly patients with diabetes mellitus: evidence from NHANES 2007-2016.BMC geriatrics · 2024Article
- Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population.Cardiovascular diabetology · 2024Article
- Association of the triglyceride glucose index with all-cause and cardiovascular mortality in a general population of Iranian adults.Cardiovascular diabetology · 2024Article
- Baseline triglyceride-glucose, body mass index, end-diastolic internal diameter of the left atria and creatinine are independent predictors for pulmonary hypertension in coronary artery disease patients after percutaneous coronary intervention treatments.Biomarkers in medicine · 2024Article
- Association of triglyceride-glucose index, low and high-density lipoprotein cholesterol with all-cause and cardiovascular disease mortality in generally Chinese elderly: a retrospective cohort study.Frontiers in endocrinology · 2024Article
- Association of cardiometabolic factors and insulin resistance surrogates with mortality in participants from the Korean Genome and Epidemiology Study.Lipids in health and disease · 2023Article
- Triglyceride glucose index as a predictor of mortality in middle-aged and elderly patients with type 2 diabetes in the US.Scientific reports · 2023Article
- Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study.Cardiovascular diabetology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the association between the triglyceride glucose (TyG) index and all-cause and cause-specific mortality in middle age and elderly population. METHODS AND
resultsA total of 9,254 participants with age ≥ 45 years were enrolled from the National Health and Nutrition Examination Survey cycle of 1999-2014. The TyG index was determined as ln [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. Primary outcomes were all-cause mortality and cause-specific mortality (cardiovascular diseases and malignant neoplasms). The association between the levels of TyG and the risk of mortality was explored with Cox regression models. After a median follow-up of 7.6 years, 1,774 all-cause death occurred. Univariate analysis showed that the TyG was associated with all-cause mortality (hazard ratio [HR] 1.18, 95% confidence interval [CI] [1.11,1.26]; p < 0.001). Furthermore, multivariate-adjusted analysis found that the third TyG quartile (8.72 ~ 9.16) was associated with the lowest risk of all-cause mortality (HR 0.84, 95%CI [0.73, 0.98]; p < 0.05). Restricted cubic splines showed that the association between levels of TyG index and the risk of all-cause mortality was non-linear (p for nonlinearity < 0.001) and the inflection point was 9.18 using threshold effect analysis. The HR was 0.82 (95%CI [0.71,0.96]) below 9.18 while the HR was 1.32 (95%CI [1.12,1.55]) above 9.18.
conclusionTyG index was U-shaped associated with all-cause mortality and the TyG index associated with the lowest risk of all-cause mortality was 9.18.
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