ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2022
Carcinogenic components of tobacco and tobacco smoke: A 2022 update.
Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 2 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- Meta-analysis of smoking and breast cancer risk: by age of smoking initiation.Breast cancer (Tokyo, Japan) · 2025Pooled it
- Maternal smoking, consumption of alcohol, and caffeinated beverages during pregnancy and the risk of childhood brain tumors: a meta-analysis of observational studies.BMC public health · 2024Pooled it
- Impact of Survey Item Wording and Response Options on Prevalence of Beliefs About Nicotine Causing Cancer: A Randomized Survey Experiment.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
- Quantitative Analysis of Small Particles Present in Surgical Smoke Generated During Breast Surgery.Medicina (Kaunas, Lithuania) · 2025Trial
- Efficacy of topical tranexamic acid soaked absorbable gelfoam in relieving post-extraction pain in warfarin patients: a randomized, triple-blinded, split-mouth, active-controlled clinical trial.BMC oral health · 2024Trial
- Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease.Nature cardiovascular research · 2026Article
- Article
- Tobacco-related urinary biomarkers and lung cancer risk in women, a case-cohort analysis.Journal of the National Cancer Institute · 2026Article
- Associations between smoking, tobacco types, and depression in middle-aged and elderly Chinese individuals: a cross-sectional analysis from the CHARLS study.Substance abuse treatment, prevention, and policy · 2026Observational
- SYVN1-provoked RASA1 ubiquitination promotes pulmonary inflammation in chronic obstructive pulmonary disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Identification of a Potential Direct-Acting DNA Ethylating Agent Originating from the Synthetic Cooling AgentChemical research in toxicology · 2026Article
- Frequent Detection of Abasic Sites andChemical research in toxicology · 2026Article
- Occurrence, Sources, and Health Risks of Chlorinated Paraffins and Environmental Persistent Free Radicals in Urban PMACS omega · 2026Article
- Global burden of lung cancer attributable to secondhand smoke (1990-2021) and predictive trends to 2035.Medicine · 2026Article
- Long noncoding RNAs at the crossroads of smoking, oxidative stress, inflammation, and lung disease.Archives of toxicology · 2026Review
- The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study.Clinical epigenetics · 2026Article
- Multi-omics, molecular modeling and experimental analysis of carcinogen benzo(a)pyrene promoting the progression of laryngeal cancer.Molecular diversity · 2026Article
- Phosphorus Intake and Cancer Risk: A Theoretical-Conceptual Model and Hypothesis for Population-Study Replication.Nutrients · 2026Article
- Compartmental analysis of the pulmonary proteome reveals novel functions of the aryl hydrocarbon receptor.Respiratory research · 2026Article
- Relationship of Urinary Mercapturic Acids of Selected Tobacco Smoke Constituents to Chronic Obstructive Pulmonary Disease in Cigarette Smokers of the Singapore Chinese Health Study.Chemical research in toxicology · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds, many of which have been recognized as hazardous to human health by regulatory agencies. In 2012, the U.S. Food and Drug Administration established a list of harmful and potentially harmful constituents in unburned tobacco and tobacco smoke, 79 of which are considered as carcinogens. Over the past 10 years, with advancing analytical technology, significant amounts of new data have been published, increasing our understanding of levels of carcinogens in tobacco products. The International Agency for Research on Cancer (IARC) has released 35 monographs since 2012, with an increasing number of compounds in unburned tobacco and tobacco smoke classified as carcinogens. In this paper, we provide an updated list of IARC-classified carcinogens in unburned tobacco and tobacco mainstream smoke. A total of 83 carcinogens has been identified - 37 in unburned tobacco and 80 in tobacco smoke - with their occurrence levels reported since 2012. No clear decreasing trends were observed for any of these carcinogens in recent years. Surveillance of the levels of tobacco carcinogens as well as regulatory actions are needed to ensure control of their levels so that potential reduced risks of cancer and other diseases may be achieved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.