Evidence map›Paper›PMID 35643077›Full record

ReviewNeuron2022

The emergence and influence of internal states.

Steven W Flavell, Nadine Gogolla, Matthew Lovett-Barron, Moriel Zelikowsky

Abstract readReview
In one paragraph

Review in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed.

  1. Article
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  6. Fertility reversibly modulatesbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Article
  10. A single brief cue leaves a day-long internal state imprint in planarians.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. A widespread internal brain state for fentanyl withdrawal.bioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven W FlavellPicower Institute for Learning and Memory, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: flavell@mit.edu.
Nadine GogollaEmotion Research Department, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Circuits for Emotion Research Group, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany. Electronic address: ngogolla@psych.mpg.de.
Matthew Lovett-BarronDivision of Biological Sciences-Neurobiology Section, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: mlb@ucsd.edu.
Moriel ZelikowskyDepartment of Neurobiology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: moriel.zelikowsky@neuro.utah.edu.

Funding

Neuromodulatory control of collective circuit dynamics in C. elegansR01NS104892 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FLAVELL, STEVEN WILLEM · 2017 to 2021
$2.1M
Dissecting the functional organization of the serotonergic system in C. elegansR01GM135413 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FLAVELL, STEVEN WILLEM · 2020 to 2023
$1.2M
Genetic dissection of neural circuits underlying trauma, fear, and social behaviorR00MH108734 · NIMH · UNIVERSITY OF UTAH · PI ZELIKOWSKY, MORIEL · 2019 to 2021
$747k
Discovery and characterization of brain-wide neuromodulatory circuits regulating arousalR00MH112840 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOVETT-BARRON, MATTHEW · 2020 to 2022
$746k
NIGMS NIH HHS R01 GM135413NIMH NIH HHS R00 MH108734NIMH NIH HHS R00 MH112840NINDS NIH HHS R01 NS104892
6 · The paper itself

Abstract

Animal behavior is shaped by a variety of "internal states"-partially hidden variables that profoundly shape perception, cognition, and action. The neural basis of internal states, such as fear, arousal, hunger, motivation, aggression, and many others, is a prominent focus of research efforts across animal phyla. Internal states can be inferred from changes in behavior, physiology, and neural dynamics and are characterized by properties such as pleiotropy, persistence, scalability, generalizability, and valence. To date, it remains unclear how internal states and their properties are generated by nervous systems. Here, we review recent progress, which has been driven by advances in behavioral quantification, cellular manipulations, and neural population recordings. We synthesize research implicating defined subsets of state-inducing cell types, widespread changes in neural activity, and neuromodulation in the formation and updating of internal states. In addition to highlighting the significance of these findings, our review advocates for new approaches to clarify the underpinnings of internal brain states across the animal kingdom.

Indexed as

Behavior, AnimalBrainAnimalsArousalCognitionMotivationbrain-wide activityinternal statesneural circuitsneuromodulation

Identifiers

PMID35643077
PMCPMC9391310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.