Evidence map›Paper›PMID 35642944›Full record

ArticlemBio2022

A Polymorphism in the Epstein-Barr Virus EBER2 Noncoding RNA Drives

Yiping Wang, Nathan Ungerleider, Brett A Hoffman, Mehmet Kara, Paul J Farrell, Erik K Flemington, Nara Lee, Scott A Tibbetts

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026
    Review
  3. Article
  4. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Evaluation of immune sensor responses to a viral small noncoding RNA.Frontiers in cellular and infection microbiology · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yiping WangDepartment of Molecular Genetics and Microbiology, UF Health Cancer Center, UF Genetics Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Nathan UngerleiderDepartment of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, Louisiana, USA.
Brett A HoffmanDepartment of Molecular Genetics and Microbiology, UF Health Cancer Center, UF Genetics Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Mehmet KaraDepartment of Molecular Genetics and Microbiology, UF Health Cancer Center, UF Genetics Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Paul J FarrellDepartment of Infectious Disease, Imperial College Londongrid.7445.2, London, United Kingdom.ORCID 0000-0002-6754-9351
Erik K FlemingtonDepartment of Pathology, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, Louisiana, USA.
Nara LeeDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Scott A TibbettsDepartment of Molecular Genetics and Microbiology, UF Health Cancer Center, UF Genetics Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.ORCID 0000-0001-8889-1642
University of Florida Health · USTulane University · USImperial College London · GBUniversity of Pittsburgh · US

Funding

"Project 3" MHV68 IncRNA/miRNA interaction in latency and lympomagenesisP01CA214091 · NCI · UNIVERSITY OF FLORIDA · PI Scott A. Tibbetts · 2017 to 2026
$15.9M
Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesisR01CA262902 · NCI · UNIVERSITY OF FLORIDA · PI TIBBETTS, SCOTT A. · 2021 to 2025
$2.2M
Programmed splicing derangement as new EBV host cell shut-off mechanismR01CA262090 · NCI · WAYNE STATE UNIVERSITY · PI ERIK K FLEMINGTON · 2022 to 2026
$2.1M
EBV reactivation causes widespread host de novo promoter transcription and transcriptional interferenceR01CA272142 · NCI · WAYNE STATE UNIVERSITY · PI ERIK K FLEMINGTON · 2022 to 2026
$2.1M
RPMS1 circular RNAs in EBV malignanciesR01CA243793 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI FLEMINGTON, ERIK K · 2019 to 2023
$1.8M
Characterizing the Molecular Mode of Action of EBV Noncoding RNA EBER1R21AI151073 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, NARA · 2020 to 2021
$430k
Medical Research Council MR/S0022597/1Medical Research Council MR/S022597/1NCI NIH HHS P01 CA214091NCI NIH HHS R01 CA243793NCI NIH HHS R01 CA262090NCI NIH HHS R01 CA262902NCI NIH HHS R01 CA272142NIAID NIH HHS R21 AI151073
6 · The paper itself

Abstract

The oncogenic gammaherpesviruses, including human Epstein-Barr virus (EBV), human Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, γHV68, MuHV-4), are associated with numerous malignancies, including B cell lymphomas and nasopharyngeal carcinoma. These viruses employ numerous molecular strategies to colonize the host, including the expression of noncoding RNAs (ncRNAs). As the first viral ncRNAs identified, EBV-encoded RNA 1 and 2 (EBER1 and EBER2, respectively) have been investigated extensively for decades; however, their specific

Indexed as

Epstein-Barr Virus InfectionsGammaherpesvirinaeHerpesvirus 8, HumanRhadinovirusAnimalsHerpesvirus 4, HumanHumansMiceNucleotidesPolymorphism, GeneticRNA, UntranslatedRNA, ViralVirus LatencyEpstein-Barr virus encoded RNA 2NucleotidesRNA, UntranslatedRNA, ViralB lymphocytesEBEREBVEpstein-Barr virusgammaherpesviruseslatencylymphomaMHV68noncoding RNA

Identifiers

PMID35642944
PMCPMC9239156
OpenAlexW4281688848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.