ReviewJournal of musculoskeletal & neuronal interactions2022
A review of musculoskeletal adaptations in individuals following major lower-limb amputation.
Review in Journal of musculoskeletal & neuronal interactions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- User accommodation to an active microprocessor-controlled knee in individuals with unilateral transfemoral amputation: a 5-week non-randomized trial.Journal of neuroengineering and rehabilitation · 2025Trial
- [Hemodynamic study of muscle perfusion in amputees].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Observational
- Using EMG Biofeedback to Restore Closed-Loop Neural Control on a Powered Prosthetic Ankle.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Editorial: Advances in smart and adaptive prosthetic and wearable technologies.Frontiers in robotics and AI · 2026Article
- The association between temporomandibular disorders and kinematics of the sacroiliac joint: a 3D motion analysis study.BMC musculoskeletal disorders · 2025Article
- A comparative study of limb load on the healthy side of above-knee amputees after reconstruction of assistive walking devices.Medicine · 2025Article
- Bone Health Deterioration in Transfemoral Prosthetic Users: An Analytical Biomechanical Explanation.International journal for numerical methods in biomedical engineering · 2025Article
- Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.Clinical epidemiology · 2025Article
- Mortality Rates of Minor vs Major Lower Extremity Amputations in Diabetic Patients.Acta medica Lituanica · 2025Article
- User-Centered Design of Neuroprosthetics: Advancements and Limitations.CNS & neurological disorders drug targets · 2025Review
- Increased Risk of Fracture after Traumatic Amputation: A Nationwide Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- Indications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls.Scientific reports · 2023Article
- Clinical evaluation of fall risk in older adults who use lower-limb prostheses: A scoping review.Journal of the American Geriatrics Society · 2023Article
- Continuous relative phases of walking with an articulated passive ankle-foot prosthesis in individuals with a unilateral transfemoral and transtibial amputation: an explorative case-control study.Biomedical engineering online · 2023Article
- The bone mineral density and isokinetic knee strength in amputee soccer players.Revista da Associacao Medica Brasileira (1992) · 2023Article
- The experience of sensorimotor integration of a lower limb sensory neuroprosthesis: A qualitative case study.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Structural musculoskeletal adaptations following amputation, such as bone mineral density (BMD) or muscle architecture, are often overlooked despite their established contributions to gait rehabilitation and the development of adverse secondary physical conditions. The purpose of this review is to provide a summary of the existing literature investigating musculoskeletal adaptations in individuals with major lower-limb amputations to inform clinical practice and provide directions for future research. Google Scholar, PubMed, and Scopus were searched for original peer-reviewed studies that included individuals with transtibial or transfemoral amputations. Summary data of twenty-seven articles indicated reduced BMD and increased muscle atrophy in amputees compared to controls, and in the amputated limb compared to intact and control limbs. Specifically, BMD was reduced in T-scores and Z-scores, femoral neck, and proximal tibia. Muscle atrophy was evidenced by decreased thigh cross-sectional area, decreased quadriceps thickness, and increased amounts of thigh fat. Overall, amputees have impaired musculoskeletal health. Future studies should include dysvascular etiologies to address their effects on musculoskeletal health and functional mobility. Moreover, clinicians can use these findings to screen increased risks of adverse sequelae such as fractures, osteopenia/porosis, and muscular atrophy, as well as target specific rehabilitation exercises to reduce these risks.
Indexed as
Identifiers
35642706PMC9186459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.