Evidence map›Paper›PMID 35642701›Full record

ArticleJournal of musculoskeletal & neuronal interactions2022

Time course changes to structural, mechanical and material properties of bone in rats after complete spinal cord injury.

Jonathan A Williams, Carmen Huesa, Mikael J Turunen, James A Oo, Oskars Radzins, Wilf Gardner, James F C Windmill, Hanna Isaksson, K Elizabeth Tanner, John S Riddell and 1 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Jonathan A WilliamsDepartment of Biomedical Engineering, Wolfson Building, University of Strathclyde, Glasgow, UK.
Carmen HuesaCentre for Musculoskeletal Science, University of the West of Scotland, Paisley, UK.
Mikael J TurunenDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
James A OoInstitute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Oskars RadzinsBiomedical Engineering Division, James Watt School of Engineering, James Watt South Building University of Glasgow, Glasgow, UK.
Wilf GardnerInstitute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
James F C WindmillDepartment of Electronic and Electrical Engineering, Royal College Building, University of Strathclyde, Glasgow, UK.
Hanna IsakssonDepartment of Biomedical Engineering, Lund University, Sweden.
K Elizabeth TannerBiomedical Engineering Division, James Watt School of Engineering, James Watt South Building University of Glasgow, Glasgow, UK.
John S RiddellInstitute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Sylvie CoupaudDepartment of Biomedical Engineering, Wolfson Building, University of Strathclyde, Glasgow, UK.
University of Strathclyde · GBUniversity of Glasgow · GBGoethe University Frankfurt · DELund University · SEQueen Mary University of London · GBUniversity of Eastern Finland · FIUniversity of the West of Scotland · GBWates (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCharacterise the spatiotemporal trabecular and cortical bone responses to complete spinal cord injury (SCI) in young rats.

methods8-week-old male Wistar rats received T9-transection SCI and were euthanised 2-, 6-, 10- or 16-weeks post-surgery. Outcome measures were assessed using micro-computed tomography, mechanical testing, serum markers and Fourier-transform infrared spectroscopy.

resultsThe trabecular and cortical bone responses to SCI are site-specific. Metaphyseal trabecular BV/TV was 59% lower, characterised by fewer and thinner trabeculae at 2-weeks post-SCI, while epiphyseal BV/TV was 23% lower with maintained connectivity. At later-time points, metaphyseal BV/TV remained unchanged, while epiphyseal BV/TV increased. The total area of metaphyseal and mid-diaphyseal cortical bone were lower from 2-weeks and between 6- and 10-weeks post-SCI, respectively. This suggested that SCI-induced bone changes observed in the rat model were not solely attributable to bone loss, but also to suppressed bone growth. No tissue mineral density differences were observed at any time-point, suggesting that decreased whole-bone mechanical properties were primarily the result of changes to the spatial distribution of bone.

conclusionYoung SCI rat trabecular bone changes resemble those observed clinically in adult and paediatric SCI, while cortical bone changes resemble paediatric SCI only.

Indexed as

Bone DensitySpinal Cord InjuriesAnimalsBone and BonesHumansMaleRatsRats, WistarX-Ray MicrotomographyBone Mechanical PropertiesFourier-transform Infrared SpectroscopymicroCTOsteoporosisSpinal Cord Transection

Identifiers

PMID35642701
PMCPMC9186457
OpenAlexW4282929107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.