Evidence map›Paper›PMID 35642586›Full record

ArticleFood & function2022

Combining galacto-oligosaccharides and 2'-fucosyllactose alters their fermentation kinetics by infant fecal microbiota and influences AhR-receptor dependent cytokine responses in immature dendritic cells.

Renate Akkerman, Madelon J Logtenberg, Martin Beukema, Bart J de Haan, Marijke M Faas, Erwin G Zoetendal, Henk A Schols, Paul de Vos

Open access · hybridAbstract read
In one paragraph

Article in Food & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Renate AkkermanImmunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands. r.akkerman@umcg.nl.ORCID http://orcid.org/0000-0002-0188-9097
Madelon J LogtenbergLaboratory of Food Chemistry, Wageningen University & Research, Wageningen, The Netherlands.
Martin BeukemaImmunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands. r.akkerman@umcg.nl.ORCID http://orcid.org/0000-0002-8746-817X
Bart J de HaanImmunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands. r.akkerman@umcg.nl.
Marijke M FaasImmunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands. r.akkerman@umcg.nl.
Erwin G ZoetendalLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Henk A ScholsLaboratory of Food Chemistry, Wageningen University & Research, Wageningen, The Netherlands.
Paul de VosImmunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands. r.akkerman@umcg.nl.
University Medical Center Groningen · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galacto-oligosaccharides (GOS) and 2'-fucosyllactose (2'-FL) are non-digestible carbohydrates (NDCs) that are often added to infant formula to replace the functionalities of human milk oligosaccharides (HMOs). It is not known if combining GOS and 2'-FL will affect their fermentation kinetics and subsequent immune-modulatory effects such as AhR-receptor stimulation. Here, we used an

Indexed as

CytokinesMicrobiotaDendritic CellsFecesFermentationGalactoseHumansInfantKineticsMilk, HumanOligosaccharidesTrisaccharides2'-fucosyllactoseCytokinesGalactoseOligosaccharidesTrisaccharides

Identifiers

PMID35642586
PMCPMC9208271
OpenAlexW4282918135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.