ArticleThe New phytologist2022
MYC transcription factors coordinate tryptophan-dependent defence responses and compromise seed yield in Arabidopsis.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- Vernalization attenuates age-dependent decline of glucosinolates in cabbage (Brassica oleracea ssp. capitata) through coordinated transcriptomic and metabolomic reprogramming.BMC plant biology · 2026Article
- Genome-wide identification of MYC transcription factors in Chrysanthemum morifolium and CmMYC25 promotes petal anthocyanin accumulation.Plant cell reports · 2026Article
- Transcriptomic changes associated with heat-induced susceptibility in wheat plants to Hessian fly (Diptera: Cecidomyiidae).Frontiers in plant science · 2026Article
- Transcriptomic analysis of a compatible tobacco-herbivore interaction and the role of jasmonoyl-L-isoleucine hydrolase 1 in response to growth/defense trade-off.BMC plant biology · 2025Article
- CsCOI1 regulates plant growth and defense in citrus.Horticulture research · 2025Article
- JA-Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8-SlWRKY57-SlAVT6s Module in Tomato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Special Regulation ofGenes · 2025Article
- Through the lens of bioenergy crops: advances, bottlenecks, and promises of plant engineering.The Plant journal : for cell and molecular biology · 2025Review
- The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Plant engineering: advances, bottlenecks, and promise.The Plant journal : for cell and molecular biology · 2025Article
- Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium.PLoS pathogens · 2025Article
- The cotton MYB33 gene is a hub gene regulating the trade-off between plant growth and defense in Verticillium dahliae infection.Journal of advanced research · 2024Article
- Phytohormones in a universe of regulatory metabolites: lessons from jasmonate.Plant physiology · 2024Review
- Article
- Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions.BMC biology · 2023Article
- Diversification of JAZ-MYC signaling function in immune metabolism.The New phytologist · 2023Article
- Molecular Network for Regulation of Seed Size in Plants.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Robust plant immunity negatively affects other fitness traits, including growth and seed production. Jasmonate (JA) confers broad-spectrum protection against plant consumers by stimulating the degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins, which in turn relieves repression on transcription factors (TFs) coincident with reduced growth and fecundity. The molecular mechanisms underlying JA-mediated decreases in fitness remain largely unknown. To assess the contribution of MYC TFs to growth and reproductive fitness at high levels of defence, we mutated three MYC genes in a JAZ-deficient mutant (jazD) of Arabidopsis thaliana that exhibits strong defence and low seed yield. Genetic epistasis analysis showed that de-repression of MYC TFs in jazD not only conferred strong resistance to insect herbivory but also reduced shoot and root growth, fruit size and seed yield. We also provided evidence that the JAZ-MYC module coordinates the supply of tryptophan with the production of indole glucosinolates and the proliferation of endoplasmic reticulum bodies that metabolise glucosinolates through the action of β-glucosidases. Our results establish MYCs as major regulators of growth- and reproductive-defence trade-offs and further indicate that these factors coordinate tryptophan availability with the production of amino acid-derived defence compounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.