Evidence map›Paper›PMID 35642317›Full record

ArticleJNCI cancer spectrum2022

Racial and Ethnic Disparities in Lung Cancer Screening by the 2021 USPSTF Guidelines Versus Risk-Based Criteria: The Multiethnic Cohort Study.

Jacqueline V Aredo, Eunji Choi, Victoria Y Ding, Martin C Tammemägi, Kevin Ten Haaf, Sophia J Luo, Neal D Freedman, Lynne R Wilkens, Loïc Le Marchand, Heather A Wakelee and 4 more

Abstract read
In one paragraph

Article in JNCI cancer spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Lung Cancer Screening Participation Among Indigenous Peoples Worldwide: A Systematic Review of Challenges and Opportunities.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025
    Pooled it
  3. Trial
  4. Article
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  10. Lung cancer screening: are race- and risk-aware criteria needed?Journal of the National Cancer Institute · 2026
    Article
  11. Addressing algorithmic bias in lung cancer screening eligibility.Journal of the National Cancer Institute · 2026
    Article
  12. Article
  13. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jacqueline V AredoDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0003-0559-3565
Eunji ChoiStanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1315-1433
Victoria Y DingStanford University School of Medicine, Stanford, CA, USA.
Martin C TammemägiDepartment of Health Sciences, Brock University, St. Catharines, ON, Canada.ORCID 0000-0002-4989-5058
Kevin Ten HaafDepartment of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.
Sophia J LuoStanford University School of Medicine, Stanford, CA, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0003-0074-1098
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Loïc Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.ORCID 0000-0001-5013-980X
Heather A WakeleeStanford University School of Medicine, Stanford, CA, USA.
Rafael MezaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1076-5037
Sung-Shim Lani ParkCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Summer S HanStanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2013-6883

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
Evaluation of genetic, clinical, and environmental risk factors to establish effective screening strategies for second primary lung cancerR37CA226081 · NCI · STANFORD UNIVERSITY · PI HAN, SUMMER S · 2018 to 2024
$4.3M
NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA124435NCI NIH HHS R37 CA226081NCI NIH HHS U01 CA164973
6 · The paper itself

Abstract

backgroundIn 2021, the US Preventive Services Task Force (USPSTF) revised its lung cancer screening guidelines to expand screening eligibility. We evaluated screening sensitivities and racial and ethnic disparities under the 2021 USPSTF criteria vs alternative risk-based criteria in a racially and ethnically diverse population.

methodsIn the Multiethnic Cohort, we evaluated the proportion of ever-smoking lung cancer cases eligible for screening (ie, screening sensitivity) under the 2021 USPSTF criteria and under risk-based criteria through the PLCOm2012 model (6-year risk ≥1.51%). We also calculated the screening disparity (ie, absolute sensitivity difference) for each of 4 racial or ethnic groups (African American, Japanese American, Latino, Native Hawaiian) vs White cases.

resultsAmong 5900 lung cancer cases, 43.3% were screen eligible under the 2021 USPSTF criteria. Screening sensitivities varied by race and ethnicity, with Native Hawaiian (56.7%) and White (49.6%) cases attaining the highest sensitivities and Latino (37.3%), African American (38.4%), and Japanese American (40.0%) cases attaining the lowest. Latino cases had the greatest screening disparity vs White cases at 12.4%, followed by African American (11.2%) and Japanese American (9.6%) cases. Under risk-based screening, the overall screening sensitivity increased to 75.7%, and all racial and ethnic groups had increased sensitivities (54.5%-91.9%). Whereas the screening disparity decreased to 5.1% for African American cases, it increased to 28.6% for Latino cases and 12.8% for Japanese American cases.

conclusionsIn the Multiethnic Cohort, racial and ethnic disparities decreased but persisted under the 2021 USPSTF lung cancer screening guidelines. Risk-based screening through PLCOm2012 may increase screening sensitivities and help to reduce disparities in some, but not all, racial and ethnic groups. Further optimization of risk-based screening strategies across diverse populations is needed.

Indexed as

Early Detection of CancerLung NeoplasmsCohort StudiesEthnicityHumansMass Screening

Identifiers

PMID35642317
PMCPMC9156850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.