Evidence map›Paper›PMID 35642193›Full record

ReviewERJ open research2022

Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis.

Christopher C Huntley, Ketan Patel, Shahnoor-E-Salam Bil Bushra, Farah Mobeen, Michael N Armitage, Anita Pye, Chloe B Knight, Alyaa Mostafa, Marie Kershaw, Aishah Z Mughal and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Recovery of lung function during the first year after COVID-19: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
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  14. Cardiopulmonary Complications after Pulmonary Embolism in COVID-19.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Christopher C HuntleyOccupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK.ORCID https://orcid.org/0000-0002-0340-3492
Ketan PatelInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Shahnoor-E-Salam Bil BushraUniversity of Birmingham, Birmingham, UK.
Farah MobeenUHB NHS Foundation Trust, Birmingham, UK.
Michael N ArmitageUniversity Hospitals Coventry and Warwickshire NHS Trust, Birmingham, UK.ORCID https://orcid.org/0000-0002-2131-0361
Anita PyeInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Chloe B KnightUniversity of Birmingham, Birmingham, UK.
Alyaa MostafaUniversity of Birmingham, Birmingham, UK.
Marie KershawUHB NHS Foundation Trust, Birmingham, UK.
Aishah Z MughalUniversity of Birmingham, Birmingham, UK.
Emily McKemeyUHB NHS Foundation Trust, Birmingham, UK.
Alice M TurnerInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0002-5947-3254
P Sherwood BurgeOccupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK.
Gareth I WaltersOccupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK.
University Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SARS and MERS may provide a model for predicting the long-term pulmonary consequences of COVID-19. Methods: This systematic review and meta-analysis aims to describe and compare the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19. Meta-analysis of PFT parameters (DerSimonian and Laird random-effects model) and proportion of CT features (Freeman-Tukey transformation random-effects model) were performed. Findings: Persistent reduction in the diffusing capacity for carbon monoxide following SARS and COVID-19 infection is seen at 6 months follow-up, and 12 months after MERS. Other PFT parameters recover in this time. 6 months after SARS and COVID-19, ground-glass opacity, linear opacities and reticulation persist in over 30% of patients; honeycombing and traction dilatation are reported less often. Severe/critical COVID-19 infection leads to greater CT and PFT abnormality compared to mild/moderate infection. Interpretation: Persistent diffusion defects suggestive of parenchymal lung injury occur after SARS, MERS and COVID-19 infection, but improve over time. After COVID-19 infection, CT features are suggestive of persistent parenchymal lung injury, in keeping with a post-COVID-19 interstitial lung syndrome. It is yet to be determined if this is a regressive or progressive disease.

Identifiers

PMID35642193
PMCPMC9035766
OpenAlexW4224287530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.