Evidence map›Paper›PMID 35642083›Full record

ArticleMolecular pharmaceutics2022

Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.

Francesca Ferraresso, Amy W Strilchuk, Lih Jiin Juang, Lauren G Poole, James P Luyendyk, Christian J Kastrup

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
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  7. DNA-directed assembly of multivalent lipid nanoparticles for targeted T cell gene delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  8. Review
  9. Review
  10. Decoding Undesirable Inflammatory Responses of Nucleic Acid-Delivering Lipid Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Review
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  13. Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Francesca FerraressoMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Amy W StrilchukMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Lih Jiin JuangMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Lauren G PooleDepartment of Pathobiology and Diagnostic Investigation, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48823, United States.
James P LuyendykDepartment of Pathobiology and Diagnostic Investigation, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48823, United States.
Christian J KastrupMichael Smith Laboratories and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.ORCID 0000-0003-3644-0019
University of British Columbia · CAMichigan State University · US

Funding

Novel determinants of fibrinogen pro-repair activity in acetaminophen-induced liver toxicityR01DK120289 · NIDDK · MICHIGAN STATE UNIVERSITY · PI LUYENDYK, JAMES P · 2019 to 2023
$2.2M
Novel coagulation-dependent mechanisms of liver regeneration to detect and prevent liver dysfunction after partial hepatectomyR01DK122813 · NIDDK · MICHIGAN STATE UNIVERSITY · PI LUYENDYK, JAMES P · 2020 to 2024
$2.0M
Novel mechanisms linking blood coagulation to liver fibrosisK99DK129710 · NIDDK · MICHIGAN STATE UNIVERSITY · PI POOLE, LAUREN G · 2021 to 2022
$177k
NIDDK NIH HHS K99 DK129710NIDDK NIH HHS R01 DK120289NIDDK NIH HHS R01 DK122813
6 · The paper itself

Abstract

Ionizable cationic lipids are essential for efficient

Indexed as

COVID-19NanoparticlesAmino AlcoholsAnimalsCaprylatesCationsDecanoatesHepatic Stellate CellsHepatocytesLipidsLiposomesMiceRNA, Small InterferingSARS-CoV-21-octylnonyl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate(4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)Amino AlcoholsCaprylatesCationsDecanoatesLipid NanoparticlesLipidsLiposomesRNA, Small Interferinggene therapyhemostasisnanomedicineRNA therapythrombotic thrombocytopenic purpuravon Willebrand factor

Identifiers

PMID35642083
PMCPMC9621687
OpenAlexW4281728438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.