Evidence map›Paper›PMID 35642070›Full record

ArticleBiomaterials research2022

Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering.

Thu-Trang Nguyen, Chih-Chien Hu, Rajalakshmi Sakthivel, Sasza Chyntara Nabilla, Yu-Wen Huang, Jiashing Yu, Nai-Chen Cheng, Yi-Jie Kuo, Ren-Jei Chung

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Article in Biomaterials research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thu-Trang Nguyen *Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan.
Chih-Chien Hu *Bone and Joint Research Center, Chang Gung Memorial Hospital, Linko, Taiwan.
Rajalakshmi SakthivelDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan.
Sasza Chyntara NabillaDepartment of Materials, University of Oxford, Oxford, UK.
Yu-Wen HuangDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan.
Jiashing YuDepartment of Chemical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan.
Nai-Chen ChengDepartment of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Yi-Jie KuoDepartment of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. benkuo5@tmu.edu.tw.
Ren-Jei ChungDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan. rjchung@ntut.edu.tw.ORCID http://orcid.org/0000-0002-0655-3680

Funding

Ministry of Science and Technology, Taiwan MOST 107-2221-E-027-014Ministry of Science and Technology, Taiwan MOST 109-2622-E-027-003-CC3National Taipei University of Technology Chang Gung Memorial Hospital Joint Research Program (NTUT-CGMH-110-03 (CORPG3L0121))National Taipei University of Technology National Taipei University of Technology
6 · The paper itself

Abstract

backgroundAll types of movements involve the role of articular cartilage and bones. The presence of cartilage enables bones to move over one another smoothly. However, repetitive microtrauma and ischemia as well as genetic effects can cause an osteochondral lesion. Numerous treatment methods such as microfracture surgergy, autograft, and allograft, have been used, however, it possesses treatment challenges including prolonged recovery time after surgery and poses a financial burden on patients. Nowadays, various tissue engineering approaches have been developed to repair bone and osteochondral defects using biomaterial implants to induce the regeneration of stem cells. 

methodsIn this study, a collagen (Col)/γ-polyglutamate acid (PGA)/hydroxyapatite (HA) composite scaffold was fabricated using a 3D printing technique. A Col/γ-PGA/HA 2D membrane was also fabricated for comparison. The scaffolds (four layers) were designed with the size of 8 mm in diameter and 1.2 mm in thickness. The first layer was HA/γ-PGA and the second to fourth layers were Col/γ-PGA. In addition, a 2D membrane was constructed from hydroxyapatite/γ-PGA and collagen/γ-PGA with a ratio of 1:3. The biocompatibility property and degradation activity were investigated for both scaffold and membrane samples. Rat bone marrow mesenchymal stem cells (rBMSCs) and human adipose-derived stem cells (hADSCs) were cultured on the samples and were tested in-vitro to evaluate cell attachment, proliferation, and differentiation. In-vivo experiments were performed in the rat and nude mice models.

resultsIn-vitro and in-vivo results show that the developed scaffold is of well biodegradation and biocompatible properties, and the Col-HA scaffold enhances the mechanical properties for osteochondrogenesis in both in-vitro and animal trials.

conclusionsThe composite would be a great biomaterial application for bone and osteochondral regeneration.

Indexed as

3D printingBone and osteochondralCollagenHydroxyapatitePolyglutamate acid

Identifiers

PMID35642070
PMCPMC9158383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.