Evidence map›Paper›PMID 35642036›Full record

ArticleJournal of nanobiotechnology2022

Targeted delivery of fat extract by platelet membrane-cloaked nanocarriers for the treatment of ischemic stroke.

Cheng Wang, Xuewei Yang, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Cheng Wang *School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Xuewei Yang *Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China.
Yixu JiangSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Lin QiSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Deli ZhugeDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China.
Tongtong XuSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Yiyan GuoSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Mingwu DengDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, 639 Zhi Zao Ju Road, Shanghai, 200011, China.
Wenjie ZhangDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, 639 Zhi Zao Ju Road, Shanghai, 200011, China.
Dongyan TianDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China.
Qingqing YinDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China.
Li LiDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China.
Zhijun ZhangSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Yongting WangSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Guo-Yuan YangSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China.
Yijie ChenDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, 325027, China. chenyijie@wmu.edu.cn.
Yaohui TangSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China. yaohuitang@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-9603-2650
Shanghai Jiao Tong University · CNWenzhou Medical University · CN

Funding

Education and Scientific Research Project of Shanghai 2019-01-07-00-02-E00064Key Technologies Research and Development Program 2019YFA0112000National Natural Science Foundation of China 81771244National Natural Science Foundation of China 81771251National Natural Science Foundation of China 81801170National Natural Science Foundation of China 81870921National Natural Science Foundation of China 81974179National Natural Science Foundation of China 82071284Natural Science Foundation of Zhejiang Province LR22H150001Shanghai Association for Science and Technology 20JC1411900Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research 2019CXJQ01Shanghai Rising-Star Program 21QA1405200Wenzhou Municipal Science and Technology Bureau 2021ZY0002
6 · The paper itself

Abstract

backgroundOur previous studies suggest that human fat extract (FE) contains a variety of angiogenic factors and may provide an alternative treatment option for stroke. However, the therapeutic effect is largely limited due to its short half-life, and inaccurate targeting.

resultsHerein, we leverage the targeting abilities of platelets (PLTs) to the lesion area of stroke and Arg-Gly-Asp (RGD) peptides to the angiogenic blood vessels to develop a biomimetic nanocarrier that capable of delivering FE precisely to treat stroke. The biomimetic nanocarriers are comprised of FE-encapsulated PLGA (poly(lactic-co-glycolic acid)) core enclosed by RGD peptides decorated plasma membrane of PLTs, namely RGD-PLT@PLGA-FE. We found that RGD-PLT@PLGA-FE not only targeted damaged and inflamed blood vessels but also achieved rapid accumulation in the lesion area of ischemic brain. In addition, RGD-PLT@PLGA-FE kept a sustained release behavior of FE at the lesion site, effectively increased its half-life and promoted angiogenesis and neurogenesis with delivering neurotrophic factors including BDNF, GDNF and bFGF to the brain, that ultimately resulted in blood flow increase and neurobehavioral recovery.

conclusionsIn conclusion, our study provides a new strategy to design a biomimetic system for FE delivery and it is a promising modality for stroke therapy.

Indexed as

Ischemic StrokeStrokeBlood PlateletsDrug Delivery SystemsHumansPeptidesPeptidesAngiogenesisFat extractIschemic strokeNeurogenesisPlatelet membrane

Identifiers

PMID35642036
PMCPMC9153102
OpenAlexW4281855553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.