ArticleCardiovascular diabetology2022
Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
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131 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Triglyceride-glucose index and the prognosis of patients with heart failure: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- A meta-analysis of the prognostic value of the TyG index in heart failure.Frontiers in endocrinology · 2025Pooled it
- Interplay between triglyceride-glucose index and cardiovascular events in hypertensive patients with controlled blood pressure (SBP<140 mmHg): insights from the SPRINT trial.Frontiers in endocrinology · 2025Trial
- Metabolic-inflammatory burden predicts mortality in heart failure across population and ICU cohorts.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Prognostic value of C-reactive protein-triglyceride-glucose index in hospitalised patients with acute decompensated heart failure.BMC cardiovascular disorders · 2026Article
- Focusing on depressive symptoms in patients to mitigate the risk of pain: a nationwide, prospective cohort study.BMC public health · 2026Observational
- The association between triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events in patients with heart failure.Journal of health, population, and nutrition · 2026Article
- Differential associations between novel triglyceride-glucose-obesity indices and incident stroke in individuals with early-stage cardiovascular-kidney-metabolic syndrome: a longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Combined assessment of triglyceride-glucose index and stress hyperglycemia ratio to predict all-cause mortality in critically ill patients with intracerebral hemorrhage.BMC neurology · 2026Article
- The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A Meta-Analysis.Journal of clinical medicine research · 2026Article
- Plasma soluble triggering receptor expressed on myeloid cells 2 levels and clinical outcomes in acute decompensated heart failure: A retrospective cohort study.The Journal of international medical research · 2026Article
- Association of Triglyceride-Glucose Index With In-Hospital Malignant Arrhythmias in Older Patients With Diabetes Mellitus and Left Ventricular Aneurysm: A Retrospective Study.Reviews in cardiovascular medicine · 2026Article
- A cut-off value for endothelial dysfunction based on the triglyceride-glucose index.Scientific reports · 2026Article
- Triglyceride-glucose index and assisted reproductive outcomes in non-PCOS women: evidence from a propensity score-weighted cohort of 9,903 patients.Journal of ovarian research · 2026Article
- Assessment of Triglyceride/High-Density Lipoprotein Cholesterol Ratio and Triglyceride-Glucose Index Threshold in Patients with Chronic Kidney Disease: Evaluation of Clinical Features and Outcomes.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- The combination of visceral adiposity and triglyceride-glucose indices as predictors of cardiovascular disease incidence in middle-aged and older adults.European journal of medical research · 2026Article
- Prognostic value of the triglyceride-glucose index combined with atherogenic index of plasma for all-cause mortality in critically ill patients with chronic heart failure: a machine learning-driven retrospective cohort study.Lipids in health and disease · 2026Article
- Correlation analysis between the prevalence of hyperuricemia and the triglyceride-glucose index in adult patients with brucellosis.BMC infectious diseases · 2026Article
- Triglyceride-Glucose Index and 30-day mortality in pediatric sepsis: a retrospective cohort study based on PIC database.Frontiers in pediatrics · 2026Article
- Association of TyG with Survival and Metabolic Alterations in Severe Fever with Thrombocytopenia Syndrome: A Single- Centre Retrospective Study.Infection and drug resistance · 2026Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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Abstract
backgroundThe triglyceride glucose (TyG) index has been proposed as a reliable marker of insulin resistance (IR) and an independent predictor of cardiovascular disease risk. However, its prognostic value in patients with acute decompensated heart failure (ADHF) remains unclear.
methodsA total of 932 hospitalized patients with ADHF from January 1st, 2018 to February 1st, 2021 were included in this retrospective study. The TyG index was calculated as ln [fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2]. Patients were divided into tertiles according to TyG index values. The primary endpoints were all-cause death, cardiovascular (CV) death and major adverse cardiac and cerebral events (MACCEs) during follow-up. We used multivariate adjusted Cox proportional hazard models and restricted cubic spline analysis to investigate the associations of the TyG index with primary endpoints.
resultsDuring a median follow-up time of 478 days, all-cause death, CV death and MACCEs occurred in 140 (15.0%), 103 (11.1%) and 443 (47.9%) cases, respectively. In multivariate Cox proportional hazard models, the risk of incident primary endpoints was associated with the highest TyG tertile. After adjustment for confounding factors, hazard ratios (HRs) for the highest tertile (TyG index ≥ 9.32) versus the lowest tertile (TyG index < 8.83) were 2.09 (95% confidence interval [CI], 1.23-3.55; p = 0.006) for all-cause death, 2.31 (95% CI, 1.26-4.24; p = 0.007) for CV death and 1.83 (95% CI, 1.18-3.01; p = 0.006) for MACCEs. Restricted cubic spline analysis also showed that the cumulative risk of primary endpoints increased as TyG index increased. When the TyG index was used as a continuous variable, the hazard ratios of the three primary endpoints rapidly increased within the higher range of the TyG index (all cause death, TyG > 9.08; CV death, TyG > 9.46; MACCEs, TyG > 9.87).
conclusionsThe elevated TyG index was independently associated with poor prognosis, and thus would be useful in the risk stratification in patients with ADHF.
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