Evidence map›Paper›PMID 35641956›Full record

ReviewJournal of nanobiotechnology2022

Advances of nano drug delivery system for the theranostics of ischemic stroke.

Wei Lv, Yijiao Liu, Shengnan Li, Lingyan Lv, Hongdan Lu, Hongliang Xin

Open access · goldAbstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
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  17. How Advanced Is Nanomedicine for Atherosclerosis?International journal of nanomedicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei LvDepartment of Pharmacy, The Jiangyin Clinical College of Xuzhou Medical University, 214400, Jiangyin, China.
Yijiao LiuDepartment of Pharmacy, The Jiangyin Clinical College of Xuzhou Medical University, 214400, Jiangyin, China.
Shengnan LiDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, 211166, Nanjing, China.
Lingyan LvDepartment of Pharmacy, The Jiangyin Clinical College of Xuzhou Medical University, 214400, Jiangyin, China.
Hongdan LuDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, 211166, Nanjing, China. luhd@njmu.edu.cn.
Hongliang XinDepartment of Pharmaceutics, School of Pharmacy, Nanjing Medical University, 211166, Nanjing, China. xhl@njmu.edu.cn.ORCID http://orcid.org/0000-0002-2966-7381
Nanjing Medical University · CNXuzhou Medical College · CN

Funding

Key Science Foundation of Jiangyin Health Commission K202101National Natural Science Foundation of China 31671018National Natural Science Foundation of China 81973255
6 · The paper itself

Abstract

From the global perspective, stroke refers to a highly common cause of disability and death. Ischemic stroke (IS), attributed to blood vessel blockage, preventing the flow of blood to brain, acts as the most common form of stroke. Thus far, thrombolytic therapy is the only clinical treatment for IS with the approval from the FDA. Moreover, the physiology barrier complicates therapeutically and diagnostically related intervention development of IS. Accordingly, developing efficient and powerful curative approaches for IS diagnosis and treatment is urgently required. The advent of nanotechnology has brought dawn and hope to better curative and imaging forms for the management of IS. This work reviews the recent advances and challenges correlated with the nano drug delivery system for IS therapy and diagnosis. The overview of the current knowledge of the important molecular pathological mechanisms in cerebral ischemia and how the drugs cross the blood brain barrier will also be briefly summarized.

Indexed as

Brain IschemiaIschemic StrokeStrokeHumansNanoparticle Drug Delivery SystemPrecision MedicineNanoparticle Drug Delivery SystemBlood brain barrierBrain targetingIschemic strokeNanoparticle-based drug delivery

Identifiers

PMID35641956
PMCPMC9153106
OpenAlexW4281797821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.