Evidence map›Paper›PMID 35641938›Full record

ArticleBMC geriatrics2022

Propensity score weighted associations between financial strain and subsequent inflammatory biomarkers of aging among a representative sample of U.S. older adults.

Laura J Samuel, Melissa Hladek, Jing Tian, Laken C Roberts Lavigne, Sarah E LaFave, Sarah L Szanton

Abstract read
In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laura J SamuelJohns Hopkins University School of Nursing, 525 North Wolfe St., Baltimore, MD, 21205, USA. lsamuel@jhmi.edu.
Melissa HladekJohns Hopkins University School of Nursing, 525 North Wolfe St., Baltimore, MD, 21205, USA.
Jing TianDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Laken C Roberts LavigneJohns Hopkins University School of Nursing, 525 North Wolfe St., Baltimore, MD, 21205, USA.
Sarah E LaFaveJohns Hopkins University School of Nursing, 525 North Wolfe St., Baltimore, MD, 21205, USA.
Sarah L SzantonJohns Hopkins University School of Nursing, 525 North Wolfe St., Baltimore, MD, 21205, USA.

Funding

The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
Household income, financial stress and physiologic aging markers in low income adults across the life courseK01AG054751 · NIA · JOHNS HOPKINS UNIVERSITY · PI SAMUEL, LAURA · 2018 to 2022
$651k
Associations of Neighborhood Green Space and Social Disadvantage with Stress-Sensitive Inflammatory BiomarkersF31HL146080 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ROBERTS, LAKEN CAMILLE · 2019 to 2021
$137k
NHLBI NIH HHS F31 HL146080NIA NIH HHS K01 AG054751NIA NIH HHS U01 AG032947
6 · The paper itself

Abstract

backgroundDespite known socioeconomic disparities in aging-related outcomes, the underlying physiologic mechanisms are understudied. This study applied propensity score weighting to estimate the effect of financial strain on inflammation-related aging biomarkers among a national sample of older adults.

methodsFinancial strain severe enough to lack money for housing, utilities, medical/prescription bills or food was measured among 4,593 community-dwelling National Health and Aging Trends Study participants aged ≥ 65 years in 2016. Inverse probability propensity score weights were generated based on 2015 background characteristics, including age, gender, race/ethnicity, income to poverty ratio, education, occupation, home ownership, retirement, Sect. 8 housing, Medicaid, food/energy assistance, childhood health, marital status, and U.S. region. Sampling weights additionally accounted for study design and non-response.

resultsIn propensity score-weighted analyses adjusting for age, gender, race/ethnicity, 2017 income to poverty ratio and education, those with 2016 financial strain had 15% higher IL-6 (p = 0.026) and 20% higher CRP levels (p = 0.002) in 2017 than those who were not strained, but did not differ with regard to hemoglobin A1c or CMV. In weighted comparisons, those with financial strain did not differ from those without with regard any 2015 background characteristics.

conclusionsThese results strengthen the etiologic evidence suggesting that financial strain increases inflammatory biomarkers among older adults. Importantly, inflammation is likely a key physiologic pathway contributing to socioeconomic disparities. Therefore, research is needed to address financial strain.

Indexed as

AgingInflammationAgedBiomarkersChildHumansPropensity ScoreSocioeconomic FactorsUnited StatesBiomarkersHealth equityInflammationMetabolic functionSocioeconomic factors

Identifiers

PMID35641938
PMCPMC9158352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.