Evidence map›Paper›PMID 35641909›Full record

ArticleBMC geriatrics2022

Factors associated with change over time in quality of life of people with dementia: longitudinal analyses from the MODEM cohort study.

Derek King, Nicolas Farina, Clare Burgon, Yvonne Feeney, Sharne Berwald, Elizabeth Bustard, Laura Gallaher, Ruth Habibi, Raphael Wittenberg, Adelina Comas-Herrera and 2 more

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In one paragraph

Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Derek KingCare Policy and Evaluation Centre, London School of Economics and Political Science, London, WC2A 2AE, UK. d.king@lse.ac.uk.
Nicolas FarinaCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Clare BurgonFaculty of Medicine & Health Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
Yvonne FeeneyCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Sharne BerwaldCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Elizabeth BustardCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Laura GallaherCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Ruth HabibiCentre for Dementia Studies, Brighton and Sussex Medical School, Brighton, BN1 9QY, UK.
Raphael WittenbergCare Policy and Evaluation Centre, London School of Economics and Political Science, London, WC2A 2AE, UK.
Adelina Comas-HerreraCare Policy and Evaluation Centre, London School of Economics and Political Science, London, WC2A 2AE, UK.
Martin KnappCare Policy and Evaluation Centre, London School of Economics and Political Science, London, WC2A 2AE, UK.
Sube BanerjeeFaculty of Health, University of Plymouth, Plymouth, PL4 8AA, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch to date offers mixed evidence about the relationship between quality of life and severity of cognitive impairment in people with dementia. We aimed to investigate longitudinal changes in patient- and proxy-rated health-related quality of life (HRQL) by severity of dementia and explore factors associated with changes in HRQL over a one-year period. We used data from the MODEM longitudinal cohort study which recruited dyads of persons with clinically diagnosed dementia and their principal carer and interviewed them face-to-face at baseline and again 1 year later.

methodsQuota sampling was used to generate balanced numbers (target n = 100 for each severity level) of people with mild cognitive impairment (20+ on the standardised Mini-Mental State Examination (sMMSE)), moderate cognitive impairment (score 10 to 19), and severe cognitive impairment (score 0 to 9). Persons with dementia without an identifiable family carer or other informant (e.g., a formal/professional/paid carer) were excluded from the study. Participants answered a series of questions measuring their HRQL: DEMQOL, DEMQOL-proxy, EQ-5D-3 L, EQ-5D-3L proxy. Multiple regression models were built to understand the effects of baseline demographics and dementia symptoms (cognitive impairment, neuropsychiatric symptoms) on change in HRQL over 1 year.

resultsTwo hundred and forty-three dyads of people with clinically diagnosed dementia and carers completed baseline and follow-up interviews. Most measures of HRQL remaining relatively stable between time-points, but one index of HRQL, EQ-5D proxy, significantly declined. Depending on the HRQL measure, different factors were associated with change in HRQL. The only factor consistently associated with decline in HRQL (when compared to improvement) was having a diagnosis of a non-Alzheimer's dementia.

conclusionsDeterioration in HRQL is not an inevitable part of the dementia journey. However, people with non-Alzheimer's dementias may be more susceptible to HRQL decline. This may indicate that those with non-Alzheimer's dementia may benefit from specific support focussed on maintaining their quality of life.

Indexed as

DementiaQuality of LifeCohort StudiesHumansLongitudinal StudiesModemsSurveys and QuestionnairesAlzheimer’s diseaseCaregiverCognitive impairmentDementiaHealthLongitudinal studiesQuality of lifeWellbeing

Identifiers

PMID35641909
PMCPMC9158343

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.