Evidence map›Paper›PMID 35641908›Full record

Observational studyBMC infectious diseases2022

Usability and acceptability of oral-based HCV self-testing among key populations: a mixed-methods evaluation in Tbilisi, Georgia.

Emmanuel Fajardo, Victoria Watson, Moses Kumwenda, Dali Usharidze, Sophiko Gogochashvili, David Kakhaberi, Ana Giguashvili, Cheryl C Johnson, Muhammad S Jamil, Russell Dacombe and 3 more

Abstract readObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Acceptability and Effectiveness of Point-of-Care HCV Testing in Low- and Middle-Income Countries: A Systematic Review.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  13. Substance Use and Misuse among Sexual and Gender Minority Communities Living in Former Soviet Union Countries: A Scoping Review.International journal of sexual health : official journal of the World Association for Sexual Health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emmanuel FajardoThe Foundation for Innovative New Diagnostics (FIND), Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland.
Victoria WatsonLiverpool School of Tropical Medicine (LSTM), Liverpool, UK.
Moses KumwendaMalawi Liverpool Wellcome Trust Clinical Research Programme (MLW), Blantyre, Malawi.
Dali UsharidzeNon-Governmental Organization New Way, Tbilisi, Georgia.
Sophiko GogochashviliNon-Governmental Organization New Way, Tbilisi, Georgia.
David KakhaberiCommunity-Based Organization Equality Movement, Tbilisi, Georgia.
Ana GiguashviliNational Centre for Disease Control and Public Health of Georgia, Tbilisi, Georgia.
Cheryl C JohnsonDepartment of Global HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Muhammad S JamilDepartment of Global HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Russell DacombeLiverpool School of Tropical Medicine (LSTM), Liverpool, UK.
Ketevan StviliaNational Centre for Disease Control and Public Health of Georgia, Tbilisi, Georgia.
Philippa EasterbrookDepartment of Global HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Elena Ivanova ReipoldThe Foundation for Innovative New Diagnostics (FIND), Campus Biotech, Chemin des Mines 9, 1202, Geneva, Switzerland. Elena.Ivanova@finddx.org.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundHepatitis C virus self-testing (HCVST) is an additional approach that may expand access to HCV testing. We conducted a mixed-methods cross-sectional observational study to assess the usability and acceptability of HCVST among people who inject drugs (PWID), men who have sex with men (MSM) and transgender (TG) people in Tbilisi, Georgia.

methodsThe study was conducted from December 2019 to June 2020 among PWID at one harm reduction site and among MSM/TG at one community-based organization. We used a convergent parallel mixed-methods design. Usability was assessed by observing errors made and difficulties faced by participants. Acceptability was assessed using an interviewer-administered semi-structured questionnaire. A subset of participants participated in cognitive and in-depth interviews.

resultsA total of 90 PWID, 84 MSM and 6 TG were observed performing HCVST. PWID were older (median age 35 vs 24) and had a lower level of education compared to MSM/TG (27% vs 59%). The proportion of participants who completed all steps successfully without assistance was 60% among PWID and 80% among MSM/TG. The most common error was in sample collection and this was observed more often among PWID than MSM/TG (21% vs 6%; p = 0.002). More PWID requested assistance during HCVST compared to MSM/TG (22% vs 8%; p = 0.011). Acceptability was high in both groups (98% vs 96%; p = 0.407). Inter-reader agreement was 97% among PWID and 99% among MSM/TG. Qualitative data from cognitive (n = 20) and in-depth interviews (n = 20) was consistent with the quantitative data confirming a high usability and acceptability.

conclusionsHCVST was highly acceptable among key populations in Georgia of relatively high educational level, and most participants performed HCVST correctly. A significant difference in usability was observed among PWID compared to MSM/TG, indicating that PWID may benefit from improved messaging and education as well as options to receive direct assistance when self-testing for HCV.

Indexed as

Hepatitis CHIV InfectionsSexual and Gender MinoritiesSubstance Abuse, IntravenousAdultCross-Sectional StudiesGeorgia (Republic)HepacivirusHomosexuality, MaleHumansMaleSelf-TestingAcceptabilityGeorgiaHCVMSMOral fluidPWIDScreeningSelf-testing

Identifiers

PMID35641908
PMCPMC9154030

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.