Evidence map›Paper›PMID 35641864›Full record

ArticleAdvances in experimental medicine and biology2022

Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles.

Anandan Das, Shubhadeep Roychoudhury

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. PDT-Induced Activation Enhanced by Hormone Response to Treatment.International journal of molecular sciences · 2023
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anandan DasDepartment of Life Science and Bioinformatics, Assam University, Silchar, India.
Shubhadeep RoychoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar, India. shubhadeep1@gmail.com.ORCID https://orcid.org/0000-0003-4174-1852
Assam University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) are oxygen-containing molecules which are reactive in nature and are capable of independent existence in the body. ROS comprise mostly of free radicals that contain at least one unpaired electron. Endogenous sources are the foremost birthplaces of ROS, which include mitochondrial electron transport chain, endoplasmic reticulum and peroxisome. Conversely, numerous enzymatic pathways such as xanthine oxidase and cyclooxygenase systems are among the prominent generators of cellular ROS. Major sources of ROS in the female reproductive tract include Graafian follicles, follicular fluid, fallopian tube, peritoneal cavity and endometrium. On the contrary, leukocytes, immature spermatozoa and varicocele are the key originators of ROS in the male reproductive system. For the sake of maintaining a proper oxidative balance, cells have evolved a variety of antioxidative molecules. From the physiological perspective, ROS and antioxidants are actively involved in the regulation of myriad female reproductive processes, such as cyclic luteal and endometrial changes, follicular development, ovulation, fertilization, embryonic implantation, maintenance of pregnancy and parturition. Similarly, physiological amounts of ROS are crucial in the accomplishment of various male reproductive functions as well, which include spermatozoa maturation, capacitation, hyperactivation and acrosome reaction. This chapter highlights the birthplaces of ROS in the female and male reproductive tract along with mechanisms of their production. This chapter will also put forward specific physiological roles of these reactive molecules in upholding the structural integrity and functionality of both the reproductive systems.

Indexed as

Infertility, MaleOxidative StressAntioxidantsFemaleHumansMalePregnancyReactive Oxygen SpeciesSpermatozoaAntioxidantsReactive Oxygen SpeciesAcrosome reactionEndometriumFemaleFree radicalsHyperactivationImplantationMaleOvulationOxidative stressSpermatozoa

Identifiers

PMID35641864
OpenAlexW4285145740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.