Evidence map›Paper›PMID 35641792›Full record

SynthesisInternational orthopaedics2022

Serum biomarkers for the assessment of muscle damage in various surgical approaches in primary total hip arthroplasty: a systematic review of comparative studies.

Michael G Sarantis, Panagiotis I Mandrekas, Sophia Stasi, Konstantinos Makris, George A Macheras, Andreas F Mavrogenis, George C Babis, Vasilios S Nikolaou

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International orthopaedics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Comparison of muscle injury between piriformis muscle release and preservation in total hip arthroplasty via supercapsular percutaneously-assisted total hip approach].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michael G SarantisFourth Department of Orthopaedics, KAT Hospital, Athens, Greece.
Panagiotis I MandrekasSecond Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Sophia StasiDepartment of Physical Therapy, Laboratory of Neuromuscular and Cardiovascular Study of Motion, University of West Attica, Athens, Greece.
Konstantinos MakrisDepartment of Biochemistry, KAT Hospital, Athens, Greece.
George A MacherasFourth Department of Orthopaedics, KAT Hospital, Athens, Greece.
Andreas F MavrogenisFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece. afm@otenet.gr.ORCID http://orcid.org/0000-0003-0807-0719
George C BabisSecond Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Vasilios S NikolaouSecond Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
National and Kapodistrian University of Athens · GRKAT General Hospital of Attica · GRUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUsing serum biomarkers, this systematic review assessed soft tissue injury following different total hip arthroplasty surgical approaches. The purposes were to determine if there is any advantage between the standard and minimal invasive approaches, and to compare tissue damage of the respective surgical approaches using biomarkers such as creatine kinase, myoglobin, c-reactive protein, erythrocyte sedimentation rate, skeletal troponin and interleukins.

methodA search in Pubmed/MEDLINE, Scopus and Web of Science databases was conducted in October 2021 with the use of PRISMA guidelines. Search items were ("biomarkers" OR "markers" OR "tissue damage" OR "muscle damage") AND "approach" AND ("total hip arthroplasty" OR "total hip replacement"). Inclusion criteria were prospective, randomized, controlled trials or prospective, comparative studies, comparing serum markers for muscle damage in two or more surgical approaches for primary total hip arthroplasty. Exclusion criteria were study protocols, case reports, systematic reviews, meta-analyses, studies in non-English language or without available full text, and studies not recording biomarkers of muscle damage.

resultsInitial search revealed 508 studies; after subtraction of duplicates, and exclusion criteria, 31 studies remained for analysis. No advantage between different approaches was found when evaluating biomarkers, and no specific biomarkers had a distinct role in tissue damage in total hip arthroplasty. Anterior and minimally invasive approaches were associated with lower values of soft tissue (creatine kinase) and inflammation (c-reactive protein) biomarkers compared to the standard approaches.

conclusionMeasurement of serum biomarkers after primary total hip arthroplasty for the estimation of tissue damage has unclear or little clinical value.

trial registrationPROSPERO Registration: CRD42022303959.

Indexed as

Arthroplasty, Replacement, HipBiomarkersC-Reactive ProteinCreatine KinaseHumansMusclesProspective StudiesBiomarkersC-Reactive ProteinCreatine KinaseBiomarkersMinimally invasive surgeryMuscle damageTissue damageTissue inflammationTotal hip arthroplasty

Identifiers

PMID35641792
OpenAlexW4282005087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.