Evidence map›Paper›PMID 35641787›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

Context-dependent amygdala-prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces.

Reut Naim, Simone P Haller, Julia O Linke, Allison Jaffe, Joel Stoddard, Matt Jones, Anita Harrewijn, Katharina Kircanski, Yair Bar-Haim, Melissa A Brotman

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  6. Article
  7. Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024
    Review
  8. A New Behavioral Paradigm for Frustrative Nonreward in Juvenile Mice.Biological psychiatry global open science · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reut NaimNeuroscience and Novel Therapeutics Unit, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA. reut.naim@nih.gov.
Simone P HallerNeuroscience and Novel Therapeutics Unit, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Julia O LinkeSection on Mood Dysregulation and Neuroscience, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Allison JaffeNeuroscience and Novel Therapeutics Unit, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Joel StoddardPediatric Mental Health Institute, Children's Hospital Colorado, Department of Psychiatry & Neuroscience Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-4070-4566
Matt JonesDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Anita HarrewijnSection on Development and Affective Neuroscience, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.ORCID 0000-0001-9938-4048
Katharina KircanskiSection on Mood Dysregulation and Neuroscience, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Yair Bar-HaimSchool of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Melissa A BrotmanNeuroscience and Novel Therapeutics Unit, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Unit on Neuroscience and Novel TherapeuticsZIAMH002969 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BROTMAN, MELISSA · 2019 to 2025
$13.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
Neurocognitive Targets of Hostile Interpretation Bias Training to Treat IrritabilityK23MH113731 · NIMH · UNIVERSITY OF COLORADO DENVER · PI STODDARD, JOEL JOHNSON · 2017 to 2020
$764k
Intramural NIH HHS ZIA MH002778Intramural NIH HHS ZIA MH002781Intramural NIH HHS ZIA MH002786NIMH NIH HHS K23 MH113731
6 · The paper itself

Abstract

Irritability, defined as proneness to anger, is among the most common reasons youth are seen for psychiatric care. Youth with irritability demonstrate aberrant processing of anger-related stimuli; however, the neural mechanisms remain unknown. We applied a drift-diffusion model (DDM), a computational tool, to derive a latent behavioral metric of attentional bias to angry faces in youth with varying levels of irritability during functional magnetic resonance imaging (fMRI). We examined associations among irritability, task behavior using a DDM-based index for preferential allocation of attention to angry faces (i.e., extra-decisional time bias; Δt

Indexed as

Attentional BiasAdolescentAmygdalaAngerChildFacial ExpressionFemaleHumansIrritable MoodMagnetic Resonance ImagingMalePrefrontal Cortex

Identifiers

PMID35641787
PMCPMC9630440

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.