Evidence map›Paper›PMID 35641781›Full record

ArticleScientific reports2022

Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes.

Preksha Bhagchandani, Charles A Chang, Weichen Zhao, Luiza Ghila, Pedro L Herrera, Simona Chera, Seung K Kim

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Preksha Bhagchandani *Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Charles A Chang *Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Weichen ZhaoDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Luiza GhilaDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Pedro L HerreraDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Simona CheraDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Seung K KimDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA. seungkim@stanford.edu.
Stanford University · USUniversity of Bergen · NOUniversity of Geneva · CH

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Therapeutic targeting of human islets with recombinant regulatory T cellsU01DK123743 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K, MEYER, EVERETT · 2019 to 2022
$2.9M
In vivo systems to discover mechanisms regulating human islet alpha cell functionR01DK126482 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K, MACDONALD, PATRICK · 2020 to 2023
$2.2M
Regulation of gastrointestinal hormone signaling and metabolism by Neuromedin UR01DK107507 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2017 to 2021
$2.0M
Discovering genetic and hormonal mechanisms underlying diabetes risk from flies to humansR01DK108817 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2018 to 2022
$2.0M
Breakthrough T1D Northern California Center of ExcellenceNIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK107507NIDDK NIH HHS R01 DK108817NIDDK NIH HHS R01 DK126482NIDDK NIH HHS U01 DK123743NIH HHS R01 DK107507NIH HHS T32 GM736543
6 · The paper itself

Abstract

Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice harbor the H2

Indexed as

Diabetes Mellitus, ExperimentalIslets of LangerhansIslets of Langerhans TransplantationAnimalsMiceMice, Inbred BALB CMice, Inbred C57BLTransplantation Immunology

Identifiers

PMID35641781
PMCPMC9156753
OpenAlexW4281924557

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.