Evidence map›Paper›PMID 35641779›Full record

ArticleMolecular neurobiology2022

LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by Regulating RBFOX2-Mediated Alternative Splicing of MCL-1.

Xin He, Jianan Zhang, Yunshan Guo, Xiaowei Yang, Yunfei Huang, Dingjun Hao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  6. NcRNAs: a potential treatment for spinal cord injury.Frontiers in cellular neuroscience · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Research progress on long non-coding RNAs for spinal cord injury.Journal of orthopaedic surgery and research · 2023
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xin HeDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.
Jianan ZhangDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.
Yunshan GuoDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.
Xiaowei YangDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.
Yunfei HuangDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China.
Dingjun HaoDepartment of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University Health Science Center, No. 555, Youyi East Road, Beilin District, Xi'an, 710054, China. mixirenren61245@163.com.ORCID http://orcid.org/0000-0001-6135-5372
Xi'an Honghui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LncRNA myocardial infarction-associated transcript (MIAT) alleviates acute spinal cord injury (ASCI)-induced neuronal cell apoptosis, but the specific mechanism of it involved in regulating SCI progression needs further exploration. Here, a SCI rat model was established, followed by administration with adenovirus-mediated MIAT overexpression vector (Ad-MIAT) alone or together with Ad-RBFOX2 (RNA binding fox-1 homolog 2). The data indicated that MIAT overexpression promoted motor function recovery, improved morphology of injured tissues, and restrained neuron loss and cell apoptosis in SCI rats. Then, PC-12 cells were treated with H

Indexed as

MicroRNAsMyocardial InfarctionSpinal Cord InjuriesAlternative SplicingAnimalsApoptosisHydrogen PeroxideMyeloid Cell Leukemia Sequence 1 ProteinRatsRNA, Long NoncodingSpinal CordHydrogen PeroxideMiat long non-coding RNAMicroRNAsMyeloid Cell Leukemia Sequence 1 ProteinRNA, Long NoncodingAlternative splicingLncRNA MIATMCL-1RBFOX2Spinal cord injury

Identifiers

PMID35641779
OpenAlexW4281707944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.