ArticleMethods in molecular biology (Clifton, N.J.)2022
Population Structure and Relatedness for Genome-Wide Association Studies.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The estimation of the population structure and genetic relatedness between individuals within a collection of accessions is important in the formation of core collections for the conservation of genetic resources, uncovering the demographic history of the population under study, as well as for association studies. With the recent development of high-throughput genotyping technologies, several algorithms and methods have been developed and implemented in software to estimate the extent of genetic diversity between individuals. In this chapter, our objective is to describe methods to capture population structure and relatedness in a step-by-step fashion. To exemplify the process, two pruned datasets (14K and 243K SNP markers) were used to investigate population structure and relatedness among a soybean GWAS panel using different approaches and methods.
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