Evidence map›Paper›PMID 35641582›Full record

ArticleScientific reports2022

Salivary immunity of elite collegiate American football players infected with SARS-CoV-2 normalizes following isolation.

Joshua Granger, Eunhan Cho, Kevin Lindsey, Nathan Lemoine, Derek Calvert, Jack Marucci, Shelly Mullenix, Hollis O'Neal, Brian A Irving, Neil Johannsen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Joshua GrangerSchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Eunhan ChoSchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Kevin LindseySchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Nathan LemoineLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Derek CalvertLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Jack MarucciLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Shelly MullenixLSU Athletics, LSU, Baton Rouge, LA, 70803, USA.
Hollis O'NealLouisiana State University Health Sciences Center, Baton Rouge, LA, 70803, USA.
Brian A IrvingSchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Neil JohannsenSchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA.
Guillaume SpielmannSchool of Kinesiology, Louisiana State University, 91 Huey P. Long Fieldhouse, Baton Rouge, LA, 70803, USA. gspielmann@lsu.edu.
Louisiana State University Agricultural Center · USLouisiana State University · USPennington Biomedical Research Center · USLouisiana State University Health Sciences Center New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of COVID-19 on systemic immunity in the general population has been well characterized, however the short-term effects of COVID-19 infection on innate salivary immunity in elite-level athletes are unknown. Therefore, this study aimed to determine whether elite college football athletes had altered salivary immunity following the CDC-recommended isolation post-SARS-CoV-2 infection. Salivary samples were obtained from fourteen elite football players who tested positive for SARS-CoV-2 (n = 14), immediately after CDC-recommended isolation (average days = 14 ± 2 days) and fifteen controls who remained uninfected with SARS-CoV-2. Biomarkers of innate salivary immunity (sIgA and alpha-amylase), antimicrobial proteins (AMPs, i.e., HNP1-3, lactoferrin, LL-37) and lung inflammation (SPA, SPLI, and Neutrophil Elastase-alpha-1-antitrypsin complex) were measured. Independent student t-tests were used to determine changes in biomarkers between groups. Although all AMP levels were within normal range, Human Neutrophil Defensin 1-3 concentrations and secretion rates were higher in SARS-CoV-2+ compared to SARS-CoV-2-. This suggests that the CDC-recommended isolation period is sufficient to ensure that athletes' salivary immunity is not compromised upon return to sports, and athletes post-COVID-19 infection do not appear to be at greater risk for secondary infection than those with no history of COVID-19.

Indexed as

COVID-19FootballHumansImmunity, InnateSARS-CoV-2Universities

Identifiers

PMID35641582
PMCPMC9154042
OpenAlexW4281633007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.